Category Archives: Ideas

Regenerating the lost pancreatic β-cells in DM patients: MiRNA-208-3p increases insulin-secreting cell mass and function via down regulation of its target genes, 25/September/2016, 7.25 pm

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Regenerating the lost pancreatic β-cells in DM patients: MiRNA-208-3p  increases insulin-secreting cell mass and function via down regulation of its target genes, 25/September/2016, 7.24 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance:  Given that (1)  more than 387 … Continue reading

Posted in Ideas | Comments Off on Regenerating the lost pancreatic β-cells in DM patients: MiRNA-208-3p increases insulin-secreting cell mass and function via down regulation of its target genes, 25/September/2016, 7.25 pm

Natural product-based therapy for Cardiomyopathy: Berberine, an alkaloid isolated from the roots and bark of herbs, induces the expression of Trbp/miR-208, restores the balance between slow- and fast-twitch myofiber proteins and alleviates Cardiomyopathy via up regulation of its target gene, 25/September/2015, 7.02 pm

A recent study from the Department of Cardiology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA; and Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA shows that “Trbp regulates heart function through microRNA-mediated Sox6 repression.” This study was published in the 2 … Continue reading

Posted in Ideas | Comments Off on Natural product-based therapy for Cardiomyopathy: Berberine, an alkaloid isolated from the roots and bark of herbs, induces the expression of Trbp/miR-208, restores the balance between slow- and fast-twitch myofiber proteins and alleviates Cardiomyopathy via up regulation of its target gene, 25/September/2015, 7.02 pm

Molecular therapy for Myocardial Infarction: Pituitary tumor transforming gene (PTTG1) improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 25/September/2016, 5.55 pm

A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Molecular therapy … Continue reading

Posted in Ideas | Comments Off on Molecular therapy for Myocardial Infarction: Pituitary tumor transforming gene (PTTG1) improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 25/September/2016, 5.55 pm

Natural product therapy for pulmonary arterial hypertension: γ-Bisabolene, one of the main components in Cardamom, inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 24/September/2016, 6.16 pm

A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November  2009 issue of the journal “Nature Medicine”[the number 1 journal in General Medicine with an I.F of 28.054] by Prof. Thistlethwaite PA, Li X and others. On the foundation of … Continue reading

Posted in Ideas | Comments Off on Natural product therapy for pulmonary arterial hypertension: γ-Bisabolene, one of the main components in Cardamom, inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 24/September/2016, 6.16 pm

Regenerating the lost pancreatic β-cells in DM patients: MiRNA-4534 increases insulin-secreting cell mass and function via down regulation of its target genes, 24/September/2016, 5.15 pm

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Regenerating the lost pancreatic β-cells in DM patients: MiRNA-4534  increases insulin-secreting cell mass and function via down regulation of its target genes, 24/September/2016, 5.16 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance:  Given that (1)  more than 387 … Continue reading

Posted in Ideas | Comments Off on Regenerating the lost pancreatic β-cells in DM patients: MiRNA-4534 increases insulin-secreting cell mass and function via down regulation of its target genes, 24/September/2016, 5.15 pm

Life-extension therapy: Cocoa intake can enhance your Lifespan: Cocoa inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 24/September/2016, 5.06 pm

A recent study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published in the 2 October 2009 … Continue reading

Posted in Ideas | Comments Off on Life-extension therapy: Cocoa intake can enhance your Lifespan: Cocoa inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 24/September/2016, 5.06 pm

Natural product Life-span extension therapy: Berberine, an alkaloid isolated from the roots and bark of herbs, increases life span by suppressing mTOR pathway through up regulation of its target gene, 24/September/2016, 4.44 pm

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org or http://newbioideas.com Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/  Significance:   This study suggests, for the first time, that  Berberine, by increasing the expression of its target gene, it may suppress the expression of mTOR. Thereby, it may: … Continue reading

Posted in Ideas | Comments Off on Natural product Life-span extension therapy: Berberine, an alkaloid isolated from the roots and bark of herbs, increases life span by suppressing mTOR pathway through up regulation of its target gene, 24/September/2016, 4.44 pm

Molecular therapy for Myocardial Infarction: Lamin A improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 23/September/2016, 7.48 am

A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Molecular therapy … Continue reading

Posted in Ideas | Comments Off on Molecular therapy for Myocardial Infarction: Lamin A improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 23/September/2016, 7.48 am

Regenerating the lost pancreatic β-cells in DM patients: MiR-141-3p increases insulin-secreting cell mass and function via down regulation of its target genes, 23/September/2016, 6.45 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Regenerating the lost pancreatic β-cells in DM patients: MiR-141-3p  increases insulin-secreting cell mass and function via down regulation of its target genes, 23/September/2016, 6.45 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance:  Given that (1)  more than … Continue reading

Posted in Ideas | Comments Off on Regenerating the lost pancreatic β-cells in DM patients: MiR-141-3p increases insulin-secreting cell mass and function via down regulation of its target genes, 23/September/2016, 6.45 am

Anti-telomerase cancer therapy: Succinate, one of the components of TCA cycle, suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down regulation of its target gene, 22/September/2016, 6.48 pm

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Undisclosed information: How Succinate suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 Nature (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 … Continue reading

Posted in Ideas | Comments Off on Anti-telomerase cancer therapy: Succinate, one of the components of TCA cycle, suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down regulation of its target gene, 22/September/2016, 6.48 pm

Natural product therapy for Bone disorders: Honokiol, found in the cones, bark, and leaves of Magnolia grandiflora, inhibits osteoporosis and bone metastasis via up regulation of its target gene, 22/September/2014, 3.02 pm

A study from the Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA has reported that “miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2.” This study was published in the June 25, 2014 Nature  [I.F >42] by Prof. Wan Y, Krzeszinski and … Continue reading

Posted in Ideas | Comments Off on Natural product therapy for Bone disorders: Honokiol, found in the cones, bark, and leaves of Magnolia grandiflora, inhibits osteoporosis and bone metastasis via up regulation of its target gene, 22/September/2014, 3.02 pm

Natural product Life-span extension therapy: Onion peel extract (OPE) increases life span by suppressing mTOR pathway through up regulation of its target gene, 21/September/2016, 10.49 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org or http://newbioideas.com Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/  Significance:   This study suggests, for the first time, that  Onion peel extract, by increasing the expression of its target gene, it may suppress the expression of mTOR. Thereby, … Continue reading

Posted in Ideas | Comments Off on Natural product Life-span extension therapy: Onion peel extract (OPE) increases life span by suppressing mTOR pathway through up regulation of its target gene, 21/September/2016, 10.49 am

Immune enhancement therapy: Galectin-3 increases SOX2 expression and promotes innate immunity against bacterial infection via down regulation of its target gene, 21/September/2016, 6.40 am

A recent study from the Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection.” This study was published in the 2 March 2015 issue of the Journal “Nature Immunology” [the … Continue reading

Posted in Ideas | Comments Off on Immune enhancement therapy: Galectin-3 increases SOX2 expression and promotes innate immunity against bacterial infection via down regulation of its target gene, 21/September/2016, 6.40 am

Natural product therapy for Human Cancer: Agaricus blazei Murill (AbM) suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down regulation of its target gene, 20/September/2016, 8.09 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Undisclosed information: How Agaricus blazei Murill (AbM) extract  suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 Nature (492(7428):285-9; and I.F: >42) stating that “The TEL … Continue reading

Posted in Ideas | Comments Off on Natural product therapy for Human Cancer: Agaricus blazei Murill (AbM) suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down regulation of its target gene, 20/September/2016, 8.09 am

Natural product Life-extension therapy: Siegesbeckia glabrescens extract inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span via up regulation of its target gene, 20/September/2016, 7.41 am

A recent study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published in the 2 October 2009 … Continue reading

Posted in Ideas | Comments Off on Natural product Life-extension therapy: Siegesbeckia glabrescens extract inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span via up regulation of its target gene, 20/September/2016, 7.41 am

Natural product therapy for Human Cancer: Olea tree leaf extract suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down regulation of its target gene, 19/September/2016, 3.53 pm

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Undisclosed information: How Olea tree leaf extract  suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 Nature (492(7428):285-9; and I.F: >42) stating that “The TEL … Continue reading

Posted in Ideas | Comments Off on Natural product therapy for Human Cancer: Olea tree leaf extract suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down regulation of its target gene, 19/September/2016, 3.53 pm

Natural product Life-extension therapy: Gingko biloba extract inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span via up regulation of its target gene, 19/September/2016, 3.23 pm

A recent study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published in the 2 October 2009 … Continue reading

Posted in Ideas | Comments Off on Natural product Life-extension therapy: Gingko biloba extract inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span via up regulation of its target gene, 19/September/2016, 3.23 pm

Natural product therapy for pulmonary arterial hypertension: Olive tree leaf extract inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 18/September/2016, 10.53 am

A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November  2009 issue of the journal “Nature Medicine”[the number 1 journal in General Medicine with an I.F of 28.054] by Prof. Thistlethwaite PA, Li X and others. On the foundation of … Continue reading

Posted in Ideas | Comments Off on Natural product therapy for pulmonary arterial hypertension: Olive tree leaf extract inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 18/September/2016, 10.53 am

Vitamin therapy for Bone disorders: Delta-tocotrienol, the Vitamin-E, inhibits osteoporosis and bone metastasis via up regulation of its target gene, 18/September/2014, 10.23 am

A study from the Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA has reported that “miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2.” This study was published in the June 25, 2014 Nature  [I.F >42] by Prof. Wan Y, Krzeszinski and … Continue reading

Posted in Ideas | Comments Off on Vitamin therapy for Bone disorders: Delta-tocotrienol, the Vitamin-E, inhibits osteoporosis and bone metastasis via up regulation of its target gene, 18/September/2014, 10.23 am

Natural product therapy for Myocardial Infarction: Flavanol-rich lychee fruit extract, oligonol, improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 18/September/2016, 8.50 am

A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural … Continue reading

Posted in Ideas | Comments Off on Natural product therapy for Myocardial Infarction: Flavanol-rich lychee fruit extract, oligonol, improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 18/September/2016, 8.50 am