Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports here that: Treating p53-mutated human tumors with p63 activators: Tumor suppressor MiRNA miR-335 increases the expression of tumor suppressor p53 homologue TA-p63 via up regulation of its target gene. This data suggests that miR-335, by suppressing the expression of its down steam target gene, it will increase the transcriptional activity of tumor suppressor p53 homologue TA-p63. Given that tumor suppressor p53 is mutated in more than 50% of different human cancers, this study suggests, for the first time, a therapeutic strategy as to how mutant p53 expressing human cancer can be cured by activating its un-mutated homologous proteins.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan,Treating p53-mutated human tumors with p63 activators: Tumor suppressor MiRNA miR-335 increases the expression of tumor suppressor p53 homologue TA-p63 via up regulation of its target gene, 31/May/2014, 5.21 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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