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Dr Boominathan had shown earlier that TAp73 stabilizes the protooncogene c-Jun, but the mechanism remained elusive (http://scholarbank.nus.edu.sg/handle/10635/15006 ).  Nearly after a decade, GBMD Chief-Scientist Dr Boominathan Ph.D. identifies the mechanism through which TAp73 stabilizes c-Jun.  His results reveal that p73 increases the stability of Jun by turning on its target miRNA.  This, in turn,  suppresses the expression of a protein that targets c-Jun for degradation.

Idea Proposed byDr L Boominathan Ph.D.

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To citeBoominathan, TA-p73 stabilizes c-Jun by turning on its target miRNA , 6/May/2013, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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