miR-214 reverses high glucose and high insulin induced insulin resistance by suppressing its target gene, 17/August/2013, 13.56 August 17, 2013
The Curcumin Analog EF24 inhibits the histone deacetylase SIRT1 via suppression of its transcriptinal activator, 18/August/2013, 4.06 am August 17, 2013
Noble Laureate Prof. Carol W Greider had reported in the journal Molecular Cell (2006 Nov 3;24(3):423-32) that the cyclin-dependent kinase CDK1 regulates teomere elongation. Subsequently, Noble Laureate Prof. Elizabeth H. Blackburn had reported in the journal Cell (2009 Jan 9;136(1):50-61) that Cdk1-dependent phosphorylation of Cdc13 coordinates telomere elongation during cell-cycle progression. Based on these observations, here, Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports that the tumor suppressor p53 controls telomere elongation by suppressing CDK1 expression through its target miRNA.
Idea Proposed by: Dr L Boominathan Ph.D.
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To cite: Boominathan, The tumor suppressor p53 controls telomere elongation by suppressing CDK1 expession through its target miRNA, 17/August/2013, 17.04, http://genomediscovery.org
* Research cooperation