Connecting with Nobel's (Sudhof C Thomas) favorite work: p53/p63/p73 inhibits IGF-1 exocytosis via up regulation of its target miRNAs, 13/October/2013, 22.28

p53/p63/p73 regulates Synaptotagmin-7 expression via up regulation of its target gene, 13/October/2013, 22.00
October 13, 2013
p73 inhibits the upstream regulator of SNARE nucleation through its target gene, 13/October/2013, 22.45
October 13, 2013
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This year’s Nobel prize winner for Physiology or Medicine Prof. Sudhof C Thomas (from Stanford University, California, USA) has published a paper in the Journal Cell (2011) stating that ” Activity-dependent IGF-1 exocytosis is controlled by the Calcium-sensor synaptotoagmin-10.” This study suggests that deletion of synaptotoagmin-10 results in (i) impaired secretion of IGF-1; (ii)  smaller neurons; and (iii) an overall decrease in synapse numbers.

In connection with this finding, Dr Boominathan, Founder Director-cum-chief scientist of GBMD, reports that p53/p63/p73 inhibits IGF-1 exocytosis via up regulation of its target miRNAsThis finding suggests that p63/p73/p53 may (i) inhibit IGF-1 secretion through its target miRNAs; and (ii)  decrease synapse numbers

Idea Proposed byDr L Boominathan Ph.D.

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To citeBoominathan, Connecting with Nobel’s (Sudhof C Thomas) favorite work: p53/p63/p73 inhibits IGF-1 exocytosis via up regulation of its target miRNAs, 13/October/2013, 22.28, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

* Research cooperation

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