More to our Proof of Principle/Concept/Success of GBMD

Molecular insights into Pain Mechanism: p53/p63/p73 regulates pain perception via targeting sodium channel, voltage-gated, type XI, α- subunit, 14/November/2013, 5.41 am
November 14, 2013
Molecular insights into tumor suppression: miRNA-329 increases p53, TA-p63 and TA-p73 expression via down regulation of its target gene, 14/November/2013, 6.18 am
November 14, 2013
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More to our Proof of Principle/Concept/Success of GBMD

The GBMD’s Chief-Scientist Dr Boominathan had proposed on March 23, 2013 (and in a number of other dates in 2012 and 2013-http://genomediscovery.org/molecular-insights-into-pain-mechanism-p53p63p73-regulates-pain-perception-via-targeting-sodium-channel-voltage-gated-type-xi-%CE%B1-subunit-14november2013-5-41-am/; http://genomediscovery.org/insights-into-pain-mechanism-tumor-suppressor-p53-increases-cox-2-expression-and-prostaglandin-e2-pge2-production/; http://genomediscovery.org/hyperalgesia-p53p63p73-controls-the-severity-and-duration-of-inflammatory-pain-responses-5november2013-6-38-am/; http://genomediscovery.org/molecular-insights-into-pain-mechanism-p53-suppresses-mechanical-hyperalgesia-in-mice-via-induction-of-its-target-mirna-30september2013-7-10-am/; http://genomediscovery.org/assigning-new-function-to-an-old-pain-reliever-diclofenac-activates-a-number-of-tumor-suppressor-mirnas-by-repressing-its-target-gene-2august2013-10-41-am/ http://genomediscovery.org/assigning-new-function-to-an-old-pain-reliever-diclofenac-activates-a-number-of-tumor-suppressor-mirnas-by-repressing-its-target-gene-2august2013-10-41-am/; http://genomediscovery.org/p53p63p73-functions-as-regulators-of-pain-tolerance-6july2012/; http://genomediscovery.org/p63p73-senses-temperature-pain-and-itching-30january2013/) that p63/p73 regulates thermal and neuropathic pain [http://genomediscovery.org/p63p73-regulates-thermal-and-neuropathic-pain-23march2013-21-56/].

Evidently, on Nov 4, 2013Niklison-Chirou MV and Melino G (from Toxicology Unit, Medical Research Council, Leicester, United Kingdom) have published a paper in the high profile journal PNAS stating that “p73 null mice also have impairments in the peripheral nervous system with reduced thermal sensitivity, axon number, and myelin thickness” (http://www.ncbi.nlm.nih.gov/pubmed/24190996).  It is important to understand that this research paper was published nearly eight months (Nov 4, 2013) later from the date of publication made by Dr L Boominathan.  This serves as a strong supporting evidence for the fact that our scientific minds and ideas matches with the best in the world. 

Refer this link for our earlier success: http://genomediscovery.org/proof-of-principleconceptsuccess-of-gbmd/

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