Tumor suppression: p53, p63 and p73 regulate the expression of a new tumor suppressor gene CUX1 via induction of their target gene, 26/December/2013, 4.33 am

Prof. David J Adams  (from Experimental Cancer Genetics, Sanger Institute, Hinxton, Cambridge, UK; Department of Haematology, University of Cambridge, Hills Road, Cambridge, UK; Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge, UK) has published a paper in the Journal Nature genetics stating that “Inactivating Cux1 mutations promote tumorigenesis.” This study suggests that: 1) CUX1 mutations promote tumorigenesis; 2) CUX1 is mutated in ~1–5% of various tumors; and 3) CUX1 deficiency activates the phosphoinositide 3-kinase (PI3K) pathway.  In connection with this finding, Dr L Boominathan, Director-cum-chief scientist of GBMD, reports that: Tumor suppression: p53, p63 and p73 regulate the expression of a new tumor suppressor gene CUX1 via induction of their target gene,  26/December/2013, 4.33 am. This study may through light into a new tumor suppressor pathway involving p53 and its homologues p63 and p73 and Cux1.

Idea Proposed by: Dr L Boominathan Ph.D.

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To cite: Boominathan, Tumor suppression: p53, p63 and p73 regulate the expression of a new tumor suppressor gene CUX1 via induction of their target gene,  26/December/2013, 4.33 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

* Research cooperation