Monthly Archives: March 2014

MiRNA-based therapeutics for cancer: miR-217 increases the expression of the Arf tumor suppressor via down regulation of its target gene , 31/March/2014, 21,49

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, MiRNA-based therapeutics for cancer: miR-217 increases the expression of the Arf tumor suppressor via down regulation of its target gene , 31/March/2014, 21,49,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you cite drop us … Continue reading

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Molecular cancer therapy: Cirsiliol, a flavone isolated from Achillea fragrantissima, suppresses the expression of tumor suppressor p53 negative regulator HDM4/MDM4 via up regulation of its target gene, 30/March/2014, 17.53

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Molecular cancer therapy: Cirsiliol, a flavone isolated from Achillea fragrantissima, suppresses the expression of tumor suppressor p53 negative regulator HDM4/MDM4 via up regulation of its target gene, 30/March/2014, 17.53,  Genome-2-Bio-Medicine Discovery … Continue reading

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Insights into the treatment of atherosclerosis: Resveratrol, the longevity promoting compound, suppresses foam cell formation via down regulation of its target gene, 30/March/2014, 17.48

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Insights into the treatment of atherosclerosis: Resveratrol, the longevity promoting compound, suppresses foam cell formation via down regulation of its target gene, 30/March/2014, 17.48,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you cite drop … Continue reading

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Therapeutic insights into the treatment of atherosclerosis: BRCA1 promotes oxidized low density lipoprotein-induced foam cell formation via down regulation of its target gene, 30/March/2014, 17.43

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Therapeutic insights into the treatment of atherosclerosis: BRCA1 promotes oxidized low density lipoprotein-induced foam cell formation via down regulation of its target gene, 30/March/2014, 17.43,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you … Continue reading

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Therapeutic insights into the treatment of atherosclerosis:Tumor suppressor p53 promotes oxidized low density lipoprotein-induced foam cell formation via up regulation of its target gene, 30/March/2014, 17.37

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Therapeutic insights into the treatment of atherosclerosis:Tumor suppressor p53 promotes oxidized low density lipoprotein-induced foam cell formation via up regulation of its target gene, 30/March/2014, 17.37,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you … Continue reading

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Signal transducer and activator of transcription 3 suppresses the expression of tumor suppressor TPM1 via up regulation of its target gene , 30/March/2014, 10.14 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Signal transducer and activator of transcription 3 suppresses the expression of tumor suppressor  TPM1 via up regulation of its target gene , 30/March/2014, 10.14 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you cite drop … Continue reading

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Signal transducer and activator of transcription 3 suppresses the expression of tumor suppressor RECK via up regulation of its target gene , 30/March/2014, 10.13 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Signal transducer and activator of transcription 3 suppresses the expression of tumor suppressor RECK via up regulation of its target gene , 30/March/2014, 10.13 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you cite drop … Continue reading

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MiRNA-based therapeutics for cancer: miR-101 increases the expression of tumor suppressor p53 homologue p73 via down regulation of its target gene, 30/March/2014, 10.00 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, MiRNA-based therapeutics for cancer: miR-101 increases the expression of tumor suppressor p53 homologue p73 via down regulation of its target gene, 30/March/2014, 10.00 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you cite drop … Continue reading

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Molecular therapeutic insights into the treatment of TII-Diabetes mellitus: p63 increases hepatic insulin sensitivity and decreases liver steatosis via up regulation of its target miRNA, 30/March/2014, 9.47 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Molecular therapeutic insights into the treatment of TII-Diabetes mellitus: p63 increases hepatic insulin sensitivity and decreases liver steatosis via up regulation of its target miRNA, 30/March/2014, 9.47 am,  Genome-2-Bio-Medicine Discovery … Continue reading

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Mechainstic insights into tumor suppression: Lamin A inhibits the expression of tumor suppressor p53 and its target genes via up regulation of its target gene, 30/March/2014, 9.30 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Mechainstic insights into tumor suppression: Lamin A inhibits the expression of tumor suppressor p53 and its target genes via up regulation of its target gene, 30/March/2014, 9.30 am,  Genome-2-Bio-Medicine Discovery … Continue reading

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Insights into Cell-density-dependent miRNA Biogenesis: Tumor suppressor PTEN promotes widespread miRNA biogenesis via down regulation of its target gene, 30/March/2014, 8.11 am

Prof. Dr R I Gregory and his co-workers from Boston Children’s Hospital, MA, USA; Department of Biological Chemistry and Molecular Pharmacology and Department of Pediatrics, Harvard Medical School, Boston, MA, USA; and Harvard Stem Cell Institute, Boston, MA, USA had reported in the prestigious journal Cell (Feb 27, 2014) that “Hippo Signaling … Continue reading

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The miR-99 acts as the Longevity Promoter: miR-99 increases the life span of an individual by suppressing its target gene, 29/March/2014, 7.29 am

GBMD Director-cum-Chief-Scientist Dr L Boominathan PhD reports that miR-99 (which is part of the miR-100 cluster) may increase the lifespan of an individual.  Furthermore,     Dr Boominathan identifies the mechanism through which miR-99 increases the lifespan of an individual. This study suggests that “miR-99 … Continue reading

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Insights into the targeting of TGFβ1-Induced Epithelial-Mesenchymal Transition: SMAD7 suppresses the expression of Id-1 via up regulation of its target gene, 28/March/2014, 21.36

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Insights into the targeting of TGFβ1-Induced Epithelial-Mesenchymal Transition: SMAD7   suppresses the expression of Id-1 via up regulation of its target gene, 28/March/2014, 21.36,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you cite … Continue reading

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Antiangiogenic therapy: Tumor suppressor p53 impairs the expression of VEGF and its down stream targets that mediate angiogenesis via up regulation of its target , 28/March/2014, 21.32

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Antiangiogenic therapy: Tumor suppressor p53 impairs the expression of VEGF and its down stream targets that mediate angiogenesis via up regulation of its target , 28/March/2014, 21.32,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When … Continue reading

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Insights into the regulation of cellular senescence in aging muscle: SMAD7 suppresses the expression of PI3K regulatory subunit p85α via up regulation of its target gene, 28/March/2014, 21.27

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Insights into the regulation of cellular senescence in aging muscle: SMAD7 suppresses the expression of  PI3K regulatory subunit p85α via up regulation of its target gene, 28/March/2014, 21.27,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org … Continue reading

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Insights into the regulation of cellular senescence in aging muscle: GATA Binding Protein-6 suppresses the expression of PI3K regulatory subunit p85α via up regulation of its target gene, 28/March/2014, 21.25

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Insights into the regulation of cellular senescence in aging muscle: GATA Binding Protein-6  suppresses the expression of  PI3K regulatory subunit p85α via up regulation of its target gene, 28/March/2014, … Continue reading

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Insights into the regulation of cellular senescence in aging muscle: Ginseng suppresses the expression of PI3K regulatory subunit via up regulation of its target gene, 28/March/2014, 21.23

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Insights into the regulation of cellular senescence in aging muscle: Ginseng suppresses the expression of  PI3K regulatory subunit via up regulation of its target gene, 28/March/2014, 21.23,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org … Continue reading

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Insights into the regulation of cellular senescence in aging muscle: Ginseng suppresses the expression of IGF-1 via up regulation of its target gene, 28/March/2014, 7.01 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Insights into the regulation of cellular senescence in aging muscle: Ginseng suppresses the expression of IGF-1 via up regulation of its target gene, 28/March/2014, 7.01 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you … Continue reading

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Treating human cancer with Thunder of God vine: Celastrol, an antioxidant & anti-inflammatory drug from herb Thunder of God vine, suppresses the expression of telomerase via down regulation of its target gene, 28/March/2014, 6.46 am

Noble Laureate in Medicine (1998) Prof. Dr Ferid M (The University of Texas, Houston, Texas, USA) has suggested in a number of papers that inhibition of NOS2 (Nitric oxide synthase) may have a therapeutic value in a number of cancers. In connection with this finding, Dr L Boominathan, Director-cum-chief scientist of … Continue reading

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Treating human cancer with Thunder of God vine: Celastrol, an antioxidant & anti-inflammatory drug from herb Thunder of God vine, suppresses the expression of telomerase via down regulation of its target gene, 28/March/2014, 6.46 am

Noble Laureate in Medicine (1998) Prof. Dr Ferid M (The University of Texas, Houston, Texas, USA) has suggested in a number of papers that inhibition of NOS2 (Nitric oxide synthase) may have a therapeutic value in a number of cancers. In connection with this finding, Dr L Boominathan, Director-cum-chief scientist of … Continue reading

Comments Off on Treating human cancer with Thunder of God vine: Celastrol, an antioxidant & anti-inflammatory drug from herb Thunder of God vine, suppresses the expression of telomerase via down regulation of its target gene, 28/March/2014, 6.46 am