Monthly Archives: April 2014

Antimetastatic therapy: Rhamnetin, an O-methylated flavonoid and anti-inflammatory agent, increases the expression of tumor suppresor TIMP-3 via up regulation of its target gene, 30/March/2014, 10.07

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Antimetastatic therapy: Rhamnetin, an O-methylated flavonoid and anti-inflammatory agent, increases the expression of tumor suppresor TIMP-3 via up regulation of its target gene, 30/March/2014, 10.07,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you cite … Continue reading

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Therapeutic insight into activating tumor suppressor network in human cancer cells: Triptolide, a component of the herb Thunder of God Vine, promotes widespread miRNA biogenesis via down regulation of its target gene, 30/April/2014, 9.45 am

Profs. Drs. R I Gregory, Camargo FD and others from Boston Children’s Hospital, MA, USA; Department of Biological Chemistry and Molecular Pharmacology and Department of Pediatrics, Harvard Medical School, Boston, MA, USA; and Harvard Stem Cell Institute, Boston, MA, USA had reported in the prestigious journal Cell (Feb 27, … Continue reading

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Natural product-based miRNA-dependent cancer therapy: Green tea catechins inhibit the expansion of nephrogenic progenitors and wilms tumor formation by inducing their target gene, 30/April/2014, 9.25 am

Prof. Dr. Daley GQ and co-workers from Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Children’s Hospital Boston (Harvard Medical School Teaching Hospital), Boston, Massachusetts, USA have reported recently in the prestigious journal Genes & Development. (April 14, 2014) that Lin28 sustains early renal progenitors and induces Wilms tumor.  … Continue reading

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Tumor suppressor Menin (MEN1) suppresses the expression of C/EBP-δ via up regulation of its target, 30/April/2014, 8.43 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Tumor suppressor Menin (MEN1) suppresses the expression of  C/EBP-δ via up regulation of its target,  30/April/2014, 8.43 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you cite drop us a line … Continue reading

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Senescence: PKCα increases the expression of telomerase via down regulation of its target gene, 30/April/2014, 8.33 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Senescence: PKCα increases the expression of telomerase via down regulation of its target gene, 30/April/2014, 8.33 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you cite drop us a line at info@genomediscovery.org … Continue reading

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Regulation of metastasis: c-Myc increases the expression of glycosyl transferase Mgat4a (Mannoside acetylglucosaminyltransferase 4, isoenzyme A) via down regulation of its target gene, 30/April/2014, 8.10 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Regulation of metastasis: c-Myc increases the expression of glycosyl transferase Mgat4a (Mannoside acetylglucosaminyltransferase 4, isoenzyme A) via down regulation of its target gene, 30/April/2014, 8.10 am, Genome-2-Bio-Medicine Discovery center … Continue reading

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Targeting glycosylation to mitigate cancer metastasis: Tumor suppressor p53 suppresses the expression of glycosyl transferase Mgat4a (Mannoside acetylglucosaminyltransferase 4, isoenzyme A) via down regulation of its target gene, 30/April/2014, 8.08 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Targeting glycosylation to mitigate cancer metastasis: Tumor suppressor p53 suppresses the expression of glycosyl transferase Mgat4a (Mannoside acetylglucosaminyltransferase 4, isoenzyme A) via down regulation of its target gene, 30/April/2014, 8.08 … Continue reading

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Targeting glycosylation to mitigate cancer metastasis: Fulvestrant/Faslodex, a Selective estrogen receptor down-regulator, suppresses the expression of glycosyl transferase Mgat4a (Mannoside acetylglucosaminyltransferase 4, isoenzyme A) via up regulation of its target gene, 30/April/2014, 6.18 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Targeting glycosylation to mitigate cancer metastasis: Fulvestrant/Faslodex, a Selective estrogen receptor down-regulator, suppresses the expression of glycosyl transferase Mgat4a (Mannoside acetylglucosaminyltransferase 4, isoenzyme A) via up regulation of its target … Continue reading

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Regulation of metastasis: Menin suppresses the the Wnt/β-catenin pathway via up regulation of its target gene, 30/April/2014, 6.00 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Regulation of metastasis: Menin suppresses the the Wnt/β-catenin pathway via up regulation of its target gene, 30/April/2014, 6.00 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you cite drop us a … Continue reading

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Treating cancer with a diabetic pill: Metformin, the widely prescribed drug for TIIDM, suppresses the expression of HMGA2 via up regulation of its target gene, 30/April/2014, 5.58 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Treating cancer with a diabetic pill: Metformin, the widely prescribed drug for TIIDM, suppresses the expression of HMGA2 via up regulation of its target gene, 30/April/2014, 5.58 am, Genome-2-Bio-Medicine … Continue reading

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Treating human cancer with Thunder of God vine: Celastrol, an antioxidant & anti-inflammatory drug from the herb Thunder of God vine, increases the expression of tumor suppressor Big-h3 via down regulation of its target gene, 29/April/2014, 20.22

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Treating human cancer with Thunder of God vine: Celastrol, an antioxidant & anti-inflammatory drug from the herb Thunder of God vine, increases the expression of  tumor suppressor Big-h3 … Continue reading

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Treating human cancer with Thunder of God vine: Celastrol, an antioxidant & anti-inflammatory drug from the herb Thunder of God vine, increases the expression of tumor suppressor Big-h3 via down regulation of its target gene, 29/April/2014, 20.22

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Treating human cancer with Thunder of God vine: Celastrol, an antioxidant & anti-inflammatory drug from the herb Thunder of God vine, increases the expression of  tumor suppressor Big-h3 … Continue reading

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Treating cancer with an anti-diabetic pill: Acarbose, an anti-diabetic drug used to treat non-insulin-dependent Diabetes Mellitus, eradicates cancer by suppressing the expression of nucleotide sanitizing enzyme MTH1/NUDT1, 29/April/2014, 20.14

A study from Karolinska Institutet, Sweden shows that MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.  This study was published in the April 10, 2014 Nature by Prof. Dr Helleday T, Dr Gad H and others from Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, … Continue reading

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Targeting glioma cell invasion and metastasis: Curcumin, the major component of turmeric, suppresses the expression of matrix metalloproteinase 2 and 9 (MMP2 & MMP9) via up regulation of its target gene, 29/April/2014, 19.55

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Targeting glioma cell invasion and metastasis:  Curcumin, the major component of turmeric, suppresses the expression of matrix metalloproteinase 2 and 9 (MMP2 & MMP9) via up regulation of its target gene, … Continue reading

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Targeting glioma cell invasion and metastasis: Curcumin, the major component of turmeric, suppresses the expression of matrix metalloproteinase 2 and 9 (MMP2 & MMP9) via up regulation of its target gene, 29/April/2014, 19.55

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Targeting glioma cell invasion and metastasis:  Curcumin, the major component of turmeric, suppresses the expression of matrix metalloproteinase 2 and 9 (MMP2 & MMP9) via up regulation of its target gene, … Continue reading

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Mechanistic insights into Non-steroidal Anti-inflammatory drugs-induced tumor suppression: The analgesic drug Asprin (acetyl salicylic acid) increases the expression of 15-hydroxyprostaglandin dehydrogenase (15-PGDH/HPGD) via down regulation of its target gene, 29/April/2014, 19.33

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Mechanistic insights into Non-steroidal Anti-inflammatory drugs-induced  tumor suppression: The analgesic drug Asprin (acetyl salicylic acid) increases the expression of  15-hydroxyprostaglandin dehydrogenase (15-PGDH/HPGD) via down regulation of its target gene, 29/April/2014, 19.33, Genome-2-Bio-Medicine Discovery … Continue reading

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Mechanistic insights into Non-steroidal Anti-inflammatory drugs-induced tumor suppression: The analgesic drug Asprin (acetyl salicylic acid) increases the expression of tumor suppressor Big-h3 via down regulation of its target gene, 29/April/2014, 19.23

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Mechanistic insights into Non-steroidal Anti-inflammatory drugs-induced tumor suppression: The analgesic drug Asprin (acetyl salicylic acid) increases the expression of tumor suppressor Big-h3 via down regulation of its target gene, 29/April/2014, 19.24, Genome-2-Bio-Medicine … Continue reading

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Mechanistic insights into Non-steroidal Anti-inflammatory drugs-induced tumor suppression: The analgesic drug Asprin (acetyl salicylic acid) suppresses the expression of activator protein-1 via down regulation of its target gene, 29/April/2014, 19.21

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Mechanistic insights into Non-steroidal Anti-inflammatory drugs-induced tumor suppression: The analgesic drug Asprin (acetyl salicylic acid) suppresses the expression of activator protein-1 via down regulation of its target gene, 29/April/2014, 19.21, Genome-2-Bio-Medicine Discovery … Continue reading

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Mechanistic insights into Non-steroidal Anti-inflammatory drugs-induced tumor suppression: The analgesic drug Asprin (acetyl salicylic acid) suppresses the expression of Interleukin-2 via down regulation of its target gene, 29/April/2014, 19.19

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Mechanistic insights into Non-steroidal Anti-inflammatory drugs-induced tumor suppression: The analgesic drug Asprin (acetyl salicylic acid) suppresses the expression of Interleukin-2 via down regulation of its target gene, 29/April/2014, 19.19, Genome-2-Bio-Medicine Discovery … Continue reading

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Insights into enhancing the chemosensitivity of lung cancer cells: Acarbose, an anti-diabetic drug, inhibits the expression of autophagic modulator Beclin1 via up regulation of its target gene, 29/April/2014, 17.51

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Insights into enhancing the chemosensitivity of lung cancer cells: Acarbose, an anti-diabeti drug, inhibits the expression of autophagic modulator Beclin1 via up regulation of its target gene, 29/April/2014, 17.51,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you … Continue reading

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