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Profs. Drs. R I Gregory, Camargo FD and their co-workers from Boston Children’s Hospital, MA, USA; Department of Biological Chemistry and Molecular Pharmacology and Department of Pediatrics, Harvard Medical School, Boston, MA, USA; and Harvard Stem Cell InstituteBoston, MA, USA had reported in the prestigious journal Cell (Feb 27, 2014) that Hippo Signaling Regulates Microprocessor and Links Cell-Density-Dependent miRNA Biogenesis to Cancer”  

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: An insight into activating tumor suppressor network in human cancer cells: Silvestrol, a compound isolated from the fruits and twigs of Aglaia foveolata, promotes widespread miRNA biogenesis via down regulation of its target gene. This data may suggest that Silvestrol could function as a potent anti-cancer agent in human cancers by activating the network of tumor suppressor miRNAs.

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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To citeBoominathan, An insight into activating tumor suppressor network in human cancer cells: Silvestrol, a compound isolated from the fruits and twigs of Aglaia foveolata, promotes widespread miRNA biogenesis via down regulation of its target gene, 26/April/2014, 06.16

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