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Profs. Drs. R I Gregory, Camargo FD and their co-workers from Boston Children’s Hospital, MA, USA; Department of Biological Chemistry and Molecular Pharmacology and Department of Pediatrics, Harvard Medical School, Boston, MA, USA; and Harvard Stem Cell InstituteBoston, MA, USA had reported in the prestigious journal Cell (Feb 27, 2014) that Hippo Signaling Regulates Microprocessor and Links Cell-Density-Dependent miRNA Biogenesis to Cancer”  

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: A link between the regulation of Cell-density-dependent miRNA Biogenesis and tumor suppression: The oncomiR-17-92  suppresses widespread miRNA biogenesis via down regulation of its target gene. This data may explain how  the oncomiR miR-17-92 inactivates the network of tumor suppressor miRNAs, thereby promoting cancer.

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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To citeBoominathan, A link between the regulation of Cell-density-dependent miRNA Biogenesis and tumor suppression: The oncomiR-17-92  suppresses widespread miRNA biogenesis via down regulation of its target gene, 2/April/2014, 8.53 am

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