Noble laureate in Physiology/Medicine (1975), Prof. Dr. David Baltimore, California Institute of Technology (Caltec), California, USA, had reported in the high profile journal Proc Natl Acad Sci U S A. (2012 Mar 13;109(11):4233-8) that Oncomir miR-125b regulates hematopoiesis by targeting the gene Lin28A.
Prof. Dr. Michlewski G and his co-workers from University of Edinburgh, King’s Buildings, Edinburgh EH9 3JR, UK have reported recently in the prestigious journal Nat Commun. (April 11, 2014) that Lin28a regulates neuronal differentiation and controls miR-9 production.
On the foundation of these interesting findings, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Deciphering the molecular mechanisms of tumorigenesis: miRNA-125b increases the expression of miRNA-9 via down regulation of its target gene. This data may suggest that miR-125b and miR-9 cooperate with each other in controlling biological pathways that regulate tumorigenesis.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, Deciphering the molecular mechanisms of tumorigenesis: miRNA-125b increases the expression of miRNA-9 via down regulation of its target gene, 14/April/2014, 16.41 am
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