Profs. Drs. R I Gregory, Camargo FD and their co-workers from Boston Children’s Hospital, MA, USA; Department of Biological Chemistry and Molecular Pharmacology and Department of Pediatrics, Harvard Medical School, Boston, MA, USA; and Harvard Stem Cell Institute, Boston, MA, USA had reported in the prestigious journal Cell (Feb 27, 2014) that “Hippo Signaling Regulates Microprocessor and Links Cell-Density-Dependent miRNA Biogenesis to Cancer”
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Insights into how mt-p53 evades tumor suppressor miRNA network: Mt-p53 suppresses widespread miRNA biogenesis via up regulation of its target gene. This data may explain how mutant p53 inactivates the network of tumor suppressor miRNAs, thereby promoting cancer.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, Insights into how mt-p53 evades tumor suppressor miRNA network: Mt-p53 suppresses widespread miRNA biogenesis via up regulation of its target gene, 3/April/2014, 7.56 am
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