Treating human colon cancer with a Diabetic pill: Acarbose, an anti-diabetic drug used to treat non-insulin-dependent Diabetes Mellitus, inhibits the expression of oncogenic MiRNA-135b via up regulation of its target gene, 20/April/2014, 6.43 am

Insights into the regulation of NAD(+) levels and Sirtuin1 activity: Tumor suppressor ARF suppresses the expression of NAMPT, the rate-limiting enzyme for NAD(+) biosynthesis, via up regulation of its target gene, 20/April/2014, 6.00 am
April 20, 2014
Insights into the regulation of NAD(+) levels and Sirtuin1 activity: Genistein, an anti-cancer drug from Soya, suppresses the expression of NAMPT, the rate-limiting enzyme for NAD(+) biosynthesis, via up regulation of its target gene, 20/April/2014, 6.04 am
April 20, 2014
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A study from Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1BD, UK shows that MicroRNA-135b Promotes Cancer Progression by Acting as a Downstream Effector of Oncogenic Pathways in Colon Cancer. This study was published in the April 14, 2014 CanceCell by Prof. Dr Valeri N and others.

On the foundation of this interesting finding, Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports here that: Treating human cancer with a Diabetic pill: Acarbose, an anti-diabetic drug used to treat non-insulin-dependent Diabetes Mellitus, inhibits the expression of oncogenic MiRNA-135b via up regulation of its target gene. MiRNA-135b has been shown to promote colon cancer by (1) acting as a downstream effector of oncogenic pathways; and (2) inhibiting the expression of a number of tumor suppressor proteins. Based on this, we propose here a therapeutic strategy as to how one can cure colon cancers over-expressing miRNA-135. Taken together, this study suggests that pharmacological formulations encompassing “Acarbose or its analogues” can be used in the treatment of colon cancers. 

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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To citeBoominathanTreating human cancer with a Diabetic pill: Acarbose, an anti-diabetic drug used to treat non-insulin-dependent Diabetes Mellitus, inhibits the expression of oncogenic MiRNA-135b via up regulation of its target gene, 20/April/2014, 6.43 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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