Monthly Archives: May 2014

Insights into the treatment of Halitosis: Nitric oxide synthase 2 (inducible) activators suppress the expression of Cystathionine γ-lyase (CSE) via up regulation of their target gene, 31/May/2014, 8.55 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Insights into the treatment of Halitosis: Nitric oxide synthase 2 (inducible) activators suppress the expression of Cystathionine γ-lyase (CSE) via up regulation of their target gene, 31/May/2014, 8.55 … Continue reading

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Therapeutic Insights into augmenting Antiviral responses: Garlic increases the levels of MMP12 and Interferon-α (IFN-α) via up regulation of its target gene, 31/May/2014, 8.46 am

A study from the Department of Pathology and Laboratory Medicine, UBC James Hogg Research Centre, Institute for Heart + Lung Health, University of British Columbia, Vancouver, British Columbia, Canada has reported a new transcriptional role for MMP-12 in antiviral immunity. This study was published in … Continue reading

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Pro-Angiogenic therapy: Celastrol, an antioxidant & anti-inflammatory drug from the herb Thunder of God vine, suppresses the expression of CARD10 via up regulation of its target gene, 31/May/2014, 8.33 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Pro-Angiogenic therapy: Celastrol, an antioxidant & anti-inflammatory drug from the herb Thunder of God vine, suppresses the expression of CARD10 via up regulation of its target gene, 31/May/2014, 8.33 am, Genome-2-Bio-Medicine … Continue reading

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Pro-Angiogenic therapy: Celastrol, an antioxidant & anti-inflammatory drug from the herb Thunder of God vine, suppresses the expression of CARD10 via up regulation of its target gene, 31/May/2014, 8.33 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Pro-Angiogenic therapy: Celastrol, an antioxidant & anti-inflammatory drug from the herb Thunder of God vine, suppresses the expression of CARD10 via up regulation of its target gene, 31/May/2014, 8.33 am, Genome-2-Bio-Medicine … Continue reading

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Mechanism of MiRNA-mediated telomere regulation: MiRNA-22 increases the expression of human reverse transcriptase telomerase via down regulation of its target gene, 31/May/2014, 8.23 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Mechanism of MiRNA-mediated telomere regulation: MiRNA-22 increases the expression of human reverse transcriptase telomerase via down regulation of its target gene, 31/May/2014, 8.23 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you … Continue reading

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Natural product-based therapy for Renal cell carcinoma: Rhamnetin suppresses the expression of CD44 via up regulation of its target gene, 31/May/2014, 8.18 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Natural product-based therapy for Renal cell carcinoma: Rhamnetin suppresses the expression of CD44 via up regulation of its target gene, 31/May/2014, 8.18 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you cite drop us a … Continue reading

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Molecular mechanisms of tumorigenesis: N-Methyl-N'-Nitro-N-Nitrosoguanidine (MNNG) suppresses the expression of tumor suppressor PDCD4 via up regulation of its target gene, 31/May/2014, 7.19 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Molecular mechanisms of tumorigenesis: N-Methyl-N’-Nitro-N-Nitrosoguanidine (MNNG) suppresses the expression of tumor suppressor PDCD4 via up regulation of its target gene, 31/May/2014, 7.20 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you cite drop us a line at info@genomediscovery.org

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Molecular mechanisms of tumorigenesis: N-Methyl-N’-Nitro-N-Nitrosoguanidine (MNNG) suppresses the expression of tumor suppressor PDCD4 via up regulation of its target gene, 31/May/2014, 7.19 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Molecular mechanisms of tumorigenesis: N-Methyl-N’-Nitro-N-Nitrosoguanidine (MNNG) suppresses the expression of tumor suppressor PDCD4 via up regulation of its target gene, 31/May/2014, 7.20 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you cite drop us a line at info@genomediscovery.org

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Molecular cancer therapy: Tanshinone IIA suppresses the expression of TBPL1 via up regulation of its target gene, 31/May/2014, 7.31 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Molecular cancer therapy: Tanshinone IIA suppresses the expression of TBPL1 via up regulation of its target gene, 31/May/2014, 7.31 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you cite drop us … Continue reading

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Natural product-based therapy for Cardiovascular disorders: Garlic attenuates cardiac remodelling and ameliorates myocardial function via up regulation of its target gene, 31/May/2014, 7.13 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Natural product-based therapy for Cardiovascular disorders: Garlic attenuates cardiac remodelling and ameliorates myocardial function via up regulation of its target gene, 31/May/2014, 7.13 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you … Continue reading

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Natural product-based therapy for metastatic mesenchymal tumors (GIST, RMS and LMS): Oredontin, a compound isolated from medicinal herbs, increases the expression of tumor suppressor dystrophin (DMD) via down regulation of its target gene, 31/May/2014, 6.45 pm

A recent study from the Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA reveals that Dystrophin (DMD) is a tumor suppressor in human cancers and myogenic programs. This study was published in the May 4 2014 Nature Genetics (One of the top journal in … Continue reading

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Oxidative stress: The neem oil component oleic acid suppresses the expression of antioxidant enzyme Superoxide demuatase (SOD3) via up regulation of its target gene, 31/May/2014, 5.57 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Oxidative stress: The neem oil component oleic acid  suppresses the expression of antioxidant enzyme Superoxide demuatase (SOD3) via up regulation of its target gene, 31/May/2014, 5.57 am, Genome-2-Bio-Medicine Discovery center … Continue reading

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MiRNA-based therapy for glucose intolerance and insulin resistance: MiR-221 promotes ß-cell mass and function via down regulation of its target gene, 31/May/2014, 5.47 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, MiRNA-based therapy for glucose intolerance and insulin resistance: MiR-221 promotes ß-cell mass and function via down regulation of its target gene, 31/May/2014, 5.47 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you … Continue reading

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Mechanism of MiRNA-mediated telomere regulation: MiR-802 increases the expression of human reverse transcriptase telomerase via down regulation of its target gene, 31/May/2014, 5.43 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Mechanism of MiRNA-mediated telomere regulation: MiR-802 increases the expression of human reverse transcriptase telomerase via down regulation of its target gene, 31/May/2014, 5.43 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you … Continue reading

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Mechanistic and Therapeutic insights into Myeloproliferative neoplasms (MPN): Tumor suppressor p53 suppresses the expression of E2F6 via up regulation of its target gene, 31/May/2014, 5.41 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Mechanistic and Therapeutic insights into Myeloproliferative neoplasms (MPN): Tumor suppressor p53 suppresses the expression of E2F6  via up regulation of its target gene, 31/May/2014, 5.41 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org … Continue reading

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Insights into the treatment of Cardiac Arrhythmias: Activator protein-1 increases the expression of Connexin-43 via up regulation of its target gene, 31/May/2014, 5.38 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Insights into the treatment of Cardiac Arrhythmias: Activator protein-1 increases the expression of Connexin-43 via up regulation of its target gene, 31/May/2014, 5.38 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you … Continue reading

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Therapeutic Insights into regulatory mechanisms that activate Detoxification: C/EBP-β increases the expression of antioxidant protein Nrf2/NFE2L2 via down regulation of its target gene, 31/May/2014, 5.27 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Therapeutic Insights into regulatory mechanisms that activate Detoxification: C/EBP-β increases the expression of antioxidant protein Nrf2/NFE2L2  via down regulation of its target gene, 31/May/2014, 5.27 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you cite drop … Continue reading

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Treating p53-mutated human tumors with p63 activators: Tumor suppressor MiRNA miR-335 increases the expression of tumor suppressor p53 homologue TA-p63 via up regulation of its target gene, 31/May/2014, 5.21 am

Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports here that: Treating p53-mutated human tumors with p63 activators: Tumor suppressor MiRNA miR-335 increases the expression of tumor suppressor p53 homologue TA-p63 via up regulation of its target gene. This data suggests that miR-335, by suppressing … Continue reading

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MiRNA-based therapy for glucose intolerance and insulin resistance: MiR-802 promotes ß-cell mass and function via down regulation of its target gene, 31/May/2014, 5.08 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, MiRNA-based therapy for glucose intolerance and insulin resistance: MiR-802 promotes ß-cell mass and function via down regulation of its target gene, 31/May/2014, 5.08 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you … Continue reading

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Unearthing the molecular mechanisms that govern the Maintenance of Gut immunological homeostasis: SPOP promotes the maturation of colonic regulatory T cells via down regulation of its target gene., 30/May/2014, 15.34

A recent study from the Division of Mucosal Barriology, International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. [2] Laboratory for Bioenvironmental Epigenetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan. [3] Graduate School of Medical Life Science, Yokohama City … Continue reading

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