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Profs. Drs. R I Gregory, Camargo FD and their co-workers from Boston Children’s Hospital, MA, USA; Department of Biological Chemistry and Molecular Pharmacology and Department of Pediatrics, Harvard Medical School, Boston, MA, USA; and Harvard Stem Cell InstituteBoston, MA, USA had reported in the prestigious journal Cell (Feb 27, 2014) that Hippo Signaling Regulates Microprocessor and Links Cell-Density-Dependent miRNA Biogenesis to Cancer”  

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: A link between the regulation of Cell-density-dependent miRNA Biogenesis and tumorigenesis: Human antigen R (HuR) suppresses widespread miRNA biogenesis via down regulation of its target gene. This data may suggest that HuR could function as an oncogene by suppressing the network of tumor suppressor miRNAs.

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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To citeBoominathan, A link between the regulation of Cell-density-dependent miRNA Biogenesis and tumorigenesis: Human antigen R (HuR) suppresses widespread miRNA biogenesis via down regulation of its target gene, 7/May/2014, 14.30

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