Mechanistic insight into DNA-damage induced apoptosis: Serine-threonine kinase-4 suppresses the transcriptional activity of tumor suppressor p53 homologue p73 via down regulation of its target gene, 16/May/2014, 20.29

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A study from Department of Medical Oncology, Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA. & Functional Genomics of Cancer Unit, Division of Molecular Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, Milan, Italy shows that Rescue of Hippo coactivator YAP1 triggers DNA damage–induced apoptosis in hematological cancersThis study was published in the May, 2014 Nature Medicine (Impact factor – 27.136)  by Dr Francesca C & Dr. Giovanni Tonon, Harvard Medical School, Boston; and Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, Milan.

On the foundation of this interesting finding, Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports here that: Mechanistic insight into DNA-damage induced apoptosis: Serine-threonine kinase-4 suppresses the transcriptional activity of tumor suppressor p53 homologue p73 via down regulation of its target gene.

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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To citeBoominathanMechanistic insight into DNA-damage induced apoptosis: Serine-threonine kinase-4 suppresses the transcriptional activity of tumor suppressor p53 homologue p73 via down regulation of its target gene, 16/May/2014, 20.29, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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