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Profs. Drs. R I Gregory, Camargo FD and their co-workers from Boston Children’s Hospital, MA, USA; Department of Biological Chemistry and Molecular Pharmacology and Department of Pediatrics, Harvard Medical School, Boston, MA, USA; and Harvard Stem Cell InstituteBoston, MA, USA had reported in the prestigious journal Cell (Feb 27, 2014) that “Hippo Signaling Regulates Microprocessor and Links Cell-Density-Dependent miRNA Biogenesis to Cancer”  

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Mechanistic insight into Hepatocellular Carcinoma development: TCPOBOP, an agonist of constitutive androstane receptor, suppresses widespread miRNA biogenesis via down regulation of its target gene. This data may suggest that TCPOBOP functions as a carcinogenic agent by suppressing the network of tumor suppressor miRNAs.

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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To citeBoominathan, L, Mechanistic insight into Hepatocellular Carcinoma development: TCPOBOP, an agonist of constitutive androstane receptor, suppresses widespread miRNA biogenesis via down regulation of its target gene, 17/May/2014, 5.27 am

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