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A recent study from the Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA  shows that “USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses” 

This study was published in the Apr 28 2014 Nature Immunology (One of the top journal in Immunology with an IF of  of  26.199) by Prof. Dr SC Sun, Zou Q and others from the Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:  Therapeutic Insights into augmenting the T cell responses to tumor challenge & bacterial infection: Tumor suppressor BMP4 suppresses the negative regulator of p53 tumor suppressor MDM2 via up regulation of its target geneThis study suggests that BMP4, by suppressing the expression of USP15 through its target gene, it may decrease the expression of E3 ubiquitin ligase MDM2.  Thereby, it may increase: 1) the expression  of tumor  suppressor p53; 2) tumor cell apoptosis;  and 3) anti-tumor T-cell responses. Together, this study suggests that “BMP4 activators” may find its use in augmenting anti-tumor T-cell responses; and suppressing tumor cell proliferation.

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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To citeBoominathan, Therapeutic Insights into augmenting the T cell responses to tumor challenge & bacterial infection: Tumor suppressor BMP4 suppresses the negative regulator of p53 tumor suppressor MDM2 via up regulation of its target gene, 26/May/2014, 6.54 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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