Monthly Archives: June 2014

Natural product-based therapy for Metastatic Melanoma: 1α,25-dihydroxyvitamin D(3) increases the expression of RNA-editing enzyme ADAR1 (Adenosine Deaminase Acting on RNA) via down regulation of its target gene, 01/July/2014, 5.24 am

A study from the Ella Institute of Melanoma, Ramat-Gan, Israel has reported that “MicroRNA-mediated loss of ADAR1 in metastatic melanoma promotes tumor growth.” This study was published in the 3 June 2013 Journal of Clinical Investigations (IF: 15+) by Prof. Markel G,  Nemlich Y and others from Ella Institute of Melanoma, … Continue reading

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Natural product-based Cancer therapy: 6-Gingerol inhibits leukemia proliferation via down regulation of cell cycle-regulated protein CCNA2, 1/July/2014, 5.06 am

Idea Proposed/Formulated by: Dr L Boominathan PhD Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Natural product-based Cancer therapy: 6-Gingerol  inhibits leukemia proliferation via down regulation of cell cycle-regulated protein CCNA2, 1/July/2014, 5.06 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you cite drop us a line at info@genomediscovery.org

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MiRNAs-based Comination therapy for Hepatocellular carcinoma: miRNA-375 and miRNA-29b inhibit Hepatocarcionogenesis progression via down regulation of their target genes, 1/July/2014,4.51 am

Idea Proposed/Formulated by: Dr L Boominathan PhD Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, MiRNAs-based Comination therapy for Hepatocellular carcinoma: miRNA-375 and miRNA-29b inhibit Hepatocarcionogenesis progression via down regulation of their target genes, 1/July/2014, 4.51 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you cite drop us … Continue reading

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Molecular cancer therapy: IL-1β inhibits cancer development by suppressing the expression of nucleotide sanitizing enzyme MTH1/NUDT1, 30/June/2014, 15.03

A study from Karolinska Institutet, Stockholm, Sweden shows that MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.  This study was published in the April 10, 2014 Nature [I.F >35] by Prof. Thomas H, Dr Gad H and others from Science for Life Laboratory, Division of Translational Medicine and Chemical … Continue reading

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Insights into the treatment of Myasthenia Gravis: Epigallocatechin 3-Gallate (EGCG), the major component of Green Tea, ameliorates experimental autoimmune myastenia gravis via up regulation of its target gene, 30/June/2014, 14.53

Idea Proposed/Formulated by: Dr L Boominathan PhD Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Insights into the treatment of Myasthenia Gravis: Epigallocatechin 3-Gallate (EGCG), the major component of Green Tea, ameliorates experimental autoimmune myastenia gravis via up regulation of its target gene, 30/June/2014, 14.53,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When … Continue reading

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Antiviral therapy: Asprin inhibits pseudorabies virus (PRV) replication by inducing interferon-γ inducible protein-10 (IP-10), 30/June/2014, 14.46

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Antiviral therapy: Asprin inhibits pseudorabies virus (PRV) replication by inducing interferon-γ inducible protein-10 (IP-10), 30/June/2014, 14.46, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you cite drop us a line at info@genomediscovery.org * Research cooperation

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Treating Prostate cancer with an anti-diabetic drug: Metformin, the widely used drug in the treatment of NIDDM, suppresses the expression of Wnt5a via up regulation of its target gene, 30/June/2014, 13.06

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan,  Treating Prostate cancer with an anti-diabetic drug: Metformin, the widely used drug in the treatment of NIDDM,  suppresses the expression of Wnt5a via up regulation of its target … Continue reading

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Mechanistic insights into allergen-induced tumorigenesis: Allergen suppresses the expression of tumor suppressor protein PDCD4 via up regulation of its target gene, 30/June/2014, 13.01

Idea Proposed/Formulated by: Dr L Boominathan PhD Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Mechanistic insights into allergen-induced tumorigenesis: Allergen suppresses the expression of tumor suppressor protein PDCD4 via up regulation of its target gene, 30/June/2014, 13.01,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you cite drop us a … Continue reading

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Natural product-based treatment for Alzhemer’s disease: Garlic promotes the clearance of phosphorated tau protein via induction of autophagy adaptor protein NDP52, 30/June/2014, 12.40 pm

Prof. Dr. Johnson, Jo, and others from  the Department of Anesthesiology, University of Rochester Medical Center, University of Rochester,  New York, USA report in the prestigious journal Nature Communications (2014) that “Nrf2 reduces levels of phosphorylated tau protein by inducing autophagy adaptor protein NDP52”   On the foundation … Continue reading

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MiRNA-based therapy for Human Cancer: BMP2 suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) via up regulation of its target gene, 30/June/2014, 12.10 pm

The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the University of Colorado BioFrontiers Institute, USA has published a research paper in the 13 December 2012 Nature (492(7428):285-9; I.F: >35) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.”  This study provides mechanistic insights into how TPP1 regulates telomerase … Continue reading

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MiRNA therapeutics for Mammary cancer: BMP2 decreases DNA replication through down regulation of MCM2, 30/June/2014, 10.55 am

Prof. Dr Kouzarides and his co-workers from  Cancer Research Gurdon Institute, University of Cambridge, UK report in the prestigious journal Molecular Cell (2014) that “The Breast Cancer Oncogene EMSY Represses Transcription of Antimetastatic microRNA miR-31”   On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports … Continue reading

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MiRNAs-based Comination therapy for Hepatocellular carcinoma: miRNA-375 and miRNA-200a inhibit Hepatocarcionogenesis progression via down regulation of their target genes, 30/June/2014, 10.01 am

Idea Proposed/Formulated by: Dr L Boominathan PhD Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, MiRNAs-based Comination therapy for Hepatocellular carcinoma: miRNA-375 and miRNA-200a inhibit Hepatocarcionogenesis progression via down regulation of their target genes, 30/June/2014, 10.01 am., Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you cite drop us a line at info@genomediscovery.org * … Continue reading

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Vitamin-based treatment for Ovarian Endometriosis:1α,25-dihydroxyvitamin D(3) increases the expression of tumor suppressor NTN4 (Netrin-4) via up regulation of its target gene, 30/June/2014, 7.05 am

Idea Proposed/Formulated by: Dr L Boominathan PhD Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan,Vitamin-based treatment for Ovarian Endometriosis: 1α,25-dihydroxyvitamin D(3) increases the expression of tumor suppressor NTN4  (Netrin-4)  via up regulation of its target gene,  30/June/2014, 7.05 am., Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you cite drop … Continue reading

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Mechanism of Initiation and Progression of Salt-induced Gastric cancer: High salt-intake increases the expression of FGFR1 via down regulation of its target gene,30/June/2014, 6.05 am

Idea Proposed/Formulated by: Dr L Boominathan PhD Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Mechanism of initiation and progression of Salt-induced Gastric cancer: High salt-intake increases the expression of FGFR1 via down regulation of its target gene,  30/June/2014, 6.05 am., Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you … Continue reading

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Natural product-based treatment for Asthma: Berberine inhibits bronchial inflammation and asthma via down regulation of its target gene, 30/June/2014, 5.49 am

Idea Proposed/Formulated by: Dr L Boominathan PhD Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Natural product-based treatment for Asthma: Berberine inhibits bronchial inflammation and asthma via down regulation of its target gene,  30/June/2014, 5.49 am., Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you cite drop us a line at info@genomediscovery.org … Continue reading

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Mechanistic into MiRNA-mediated Myogenic differentiation: NRAS promotes myogenic differentiation via down regulation of Smad4, 30/June/2014, 05.43 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, L., Mechanistic into MiRNA-mediated Myogenic differentiation: NRAS promotes myogenic differentiation via down regulation of Smad4, 30/June/2014, 05.43 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you cite drop us a line … Continue reading

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Anti-metastatic therapy for Cutaneous squamous cell carcinoma: The reprogramming protein Oct-4 regulates the expression of MMP13 via up regulation of its target gene, 30/June/2014, 05.41 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, L., Anti-metastatic therapy for Cutaneous squamous cell carcinoma: The reprogramming protein Oct-4 regulates the expression of MMP13 via up regulation of its target gene, 30/June/2014, 05.41 am, Genome-2-Bio-Medicine Discovery … Continue reading

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Molecular therapy for Prostate cancer: Tumor suppressor Menin (MEN1) suppresses the expression of Wnt5a via up regulation of its target gene, 29/June/2014, 22.38

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan,  Molecular therapy for Prostate cancer: Tumor suppressor Menin (MEN1)  suppresses the expression of Wnt5a via up regulation of its target gene, 29/June/2014, 22.38, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When … Continue reading

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Ovarian Endometriosis: Cell Cycle-regulated protein Cyclin D1 suppressses the expression of NTN4 (Netrin-4) via up regulation of its target gene , 29/June/2014, 22.20

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan,  Ovarian Endometriosis: Cell Cycle-regulated protein Cyclin D1 suppressses the expression of NTN4  (Netrin-4)  via up regulation of its target gene , 29/June/2014, 22.20, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you … Continue reading

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Molecular therapy for Gastric cancer: Tanshinone IIA, a well-known chinese medicine, suppresses the expression of FGFR1 via up regulation of its target gene, 29/June/2014, 22.12

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan,  Molecular therapy for Gastric cancer: Tanshinone IIA,  a well-known chinese medicine, suppresses the expression of FGFR1 via up regulation of its target gene, 29/June/2014, 22.12, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org … Continue reading

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