High glucose inhibits the generation of cardiomyocyte-like cells from differentiated cells: High glucose inhibits cardiac reprogramming by increasing Snai expression, 17/June/2014, 10.27 am

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  • A study from the Department of Clinical and Molecular Cardiovascular ResearchKeio University School of Medicine, Shinjuku-ku Tokyo, Japan;  Department of Cardiology, Keio University School of Medicine, Shinjuku-ku Tokyo, Japan;  and  JST CREST, Shinjuku-ku Tokyo, Japan has reported that “MiR-133 promotes cardiac reprogramming by directly repressing Snai1 and silencing …

  • This study was published in the 11 June 2014 EMBO Journal by Prof. Ieda MMuraoka N and others from the Department of Clinical and Molecular Cardiovascular Research, Keio University School of Medicine, Shinjuku-ku Tokyo, Japan Department of Cardiology, Keio University School of Medicine, Shinjuku-ku Tokyo, Japan.
  • On the foundation of this interesting finding, Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports here that: High glucose inhibits the generation of cardiomyocyte-like cells from differentiated cells: High glucose inhibits cardiac reprogramming by increasing Snai expression. This study suggests that high glucose, by suppressing the expression of its target gene, it could (1) decrease the number of beating cardiomyocyte-like cells (iCMs); and (2) inhibit cardiac repair.  Taken together, this study explains how high glucose inhibits the regeneration of cardiac cells.
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Idea Proposed/Formulated by: Dr L Boominathan Ph.D.

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To citeBoominathan, High glucose inhibits the generation of cardiomyocyte-like cells from differentiated cells: High glucose inhibits cardiac reprogramming by increasing Snai expression, 17/June/2014, 10.27 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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