MiRNA-based therapy for Human Cancer: MiRNA-199 suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) via down regulation of its target gene, 26/June/2014, 12.12 pm

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The 1989 Noble prize winner in Chemistry, Prof. Thomas R. Cech, from the University of Colorado BioFrontiers Institute, USA, has published a research paper in the 13 December 2012 Nature (492(7428):285-9; I.F: >35) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.  This study provides mechanistic insights into how TPP1 regulates telomerase function.

In connection with this finding, Dr Boominathan, Founder Director-cum-chief scientist of GBMD, reports that: MiRNA-based therapy for Human Cancer:  MiRNA-199 suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) via down regulation of its target gene Remarkably, over 90% human tumors over express telomerase, suggesting that inhibition of its activity may increase the efficacy of anticancer therapy.  Together, this study suggests that pharmacological formulations containing “miRNA-199 or small molecule activators of miRNA-199” can be used in the treatment of human cancers.

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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To citeBoominathan,   MiRNA-based therapy for Human Cancer:  MiRNA-199 suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) via down regulation of its target gene, 26/June/2014, 12.12 pm,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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