MiRNA-based therapy for Metastatic Melanoma: MiRNA-100 and MiRNA-99 increase the expression of RNA-editing enzyme ADAR1(Adenosine Deaminase Acting on RNA) via down regulation of their target genes, 17/June/2014, 9.27 am

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  • A study from the Ella Institute of Melanoma, Ramat-Gan, Israel has reported that “MicroRNA-mediated loss of ADAR1 in metastatic melanoma promotes tumor growth.”
  • This study was published in the 3 June 2013 Journal of Clinical Investigations (IF: 15+) by Prof. Markel G,  Nemlich Y and others from Ella Institute of Melanoma, Ramat-Gan, Israel.
  • On the foundation of this interesting finding, Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports here that: MiRNA-based therapy for Metastatic Melanoma: MiRNA-100 and MiRNA-99 increase the expression of RNA-editing enzyme ADAR1(Adenosine Deaminase Acting on RNA) via down regulation of  their target genes. This study suggests that miR-100 and miR-99, by suppressing the expression of their target genes, they could inhibit metastatic melanoma.  Together, this study suggests that pharmacological formulations containing “MiRNA-100 or MiRNA-99” can be used to treat metastatic human tumors such as metastatic melanoma

Idea Proposed/Formulated by: Dr L Boominathan Ph.D.

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To citeBoominathan, MiRNA-based therapy for Metastatic Melanoma: MiRNA-100 and MiRNA-99 increase the expression of RNA-editing enzyme ADAR1(Adenosine Deaminase Acting on RNA) via down regulation of  their target genes,  17/June/2014, 9.27 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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