MiRNA-based therapy for Metastatic Melanoma: RREB [Ras responsive element (RRE) binding protein] decreases the expression of RNA-editing enzyme ADAR1 (Adenosine Deaminase Acting on RNA) via up regulation of its target gene, 18/June/2014, 14.18

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  • A study from the Ella Institute of Melanoma, Ramat-Gan, Israel has reported that “MicroRNA-mediated loss of ADAR1 in metastatic melanoma promotes tumor growth.”
  • This study was published in the 3 June 2013 Journal of Clinical Investigations (IF: 15+) by Prof. Markel G,  Nemlich Y and others from Ella Institute of Melanoma, Ramat-Gan, Israel.
  • On the foundation of this interesting finding, Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports here that: MiRNA-based therapy for Metastatic Melanoma: RREB [Ras responsive element (RRE) binding protein] decreases the expression of RNA-editing enzyme ADAR1 (Adenosine Deaminase Acting on RNA) via up regulation of  its target genes. This study suggests that RREB, by inducing the expression of its target gene, it could inhibit metastatic melanoma.  Together, this study suggests that pharmacological formulations containing “RREB inhibitors” can be used to treat metastatic human tumors such as metastatic melanoma

Idea Proposed/Formulated by: Dr L Boominathan Ph.D.

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To citeBoominathan, MiRNA-based therapy for Metastatic Melanoma: RREB [Ras responsive element (RRE) binding protein] decreases the expression of RNA-editing enzyme ADAR1 (Adenosine Deaminase Acting on RNA) via up regulation of  its target gene 18/June/2014, 14.18,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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