Natural product-based therapy for Human Cancer: Epigallocatechin 3-Gallate (EGCG), the major component of Green tea, suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) via up regulation of its target gene, 18/June/2014, 14.31

MiRNA-based therapy for Metastatic Melanoma: RREB [Ras responsive element (RRE) binding protein] decreases the expression of RNA-editing enzyme ADAR1 (Adenosine Deaminase Acting on RNA) via up regulation of its target gene, 18/June/2014, 14.18
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Insights into the treatment of stroke: Signal transduction and activator of transcription-3 activators protect neurons from ischemic death via up regulation of their target gene, 18/June/2014, 14.41
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The 1989 Noble prize winner in Chemistry, Prof. Thomas R. Cech, from the University of Colorado BioFrontiers Institute, USA, has published a research paper in the 13 December 2012 Nature (492(7428):285-9; I.F: >35) stating that The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.”  This study provides mechanistic insights into how TPP1 regulates telomerase function.

In connection with this finding, Dr Boominathan, Founder Director-cum-chief scientist of GBMD, reports that: Natural product-based therapy for Human Cancer:   Epigallocatechin 3-Gallate (EGCG), the major component of Green tea,  suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) via up regulation of its target gene Remarkably, over 90% human tumors over express telomerase, suggesting that inhibition of its activity may increase the efficacy of anticancer therapy.  Together, this study suggests that pharmacological formulations containing “Epigallocatechin 3-Gallate  or its analogues” can be used in the treatment of human cancers.

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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To citeBoominathan,   Natural product-based therapy for Human Cancer:   Epigallocatechin 3-Gallate (EGCG), the major component of Green tea,  suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) via up regulation of its target gene, 18/June/2014, 14.31,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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