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Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports here that: Treating p53-mutated human metastatic tumors with p63 activators: Tumor suppressor MiRNA miR-335, an activator of TAp63,  suppresses the expression of MMP9 via down regulation of its target gene. This data suggests that miR-335, by suppressing the expression of its down steam target gene, it will suppress the activity of MMP9. Given that tumor suppressor p53 is mutated in more than 50% of different human cancers, this study suggests, for the first time, a therapeutic strategy as to how mutant p53 expressing human metastatic cancer can be cured by activating its un-mutated homologous proteins.

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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To citeBoominathan,Treating p53-mutated human metastatic tumors with p63 activators: Tumor suppressor MiRNA miR-335, an activator of TAp63,  suppresses the expression of MMP9 via down regulation of its target gene, 3/June/2014, 8.24 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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