Insights into the treatment of Th2-mediated inflammation and allergic diseases: TGFβ alleviates Th2-medited inflammation and Allergy via up regulation of its target gene, 20/July/2014, 5.17 am

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A study from the University of California, Los Angeles; California Institute of Technology, Pasadena; Medical Research Council, National Institute for Medical Research, London has reported that “Transcriptomics identified a critical role for Th2 cell-intrinsic miR-155 in mediating allergy and antihelminthimmunity.”

This study was published in the July 14, 2014 Proc Natl Acad Sci U S A [I.F >10] by Prof. Wilson, The 1975 Nobel prize winner for Phyisiology/Medicine, Prof. David Baltimore, Okoye and others from the University of California, Los Angeles; California Institute of Technology, Pasadena; Medical Research Council, National Institute for Medical Research, London.

On the foundation of this interesting finding, Dr L Boominathan, Director-cum-chief Scientist of GBMDreports here that: Insights into the treatment of Th2-mediated inflammation and allergic diseases: TGFβ alleviates Th2-medited inflammation and Allergy via up regulation of its target gene. This study suggests that TGFβ, by suppressing the expression of its target gene, it could promote antihelminthimmunity. Together, this study suggests that pharmacological formulations encompassing “TGFβ activators”  can be used to treat inflammation and allergic  diseases.

Idea Proposed/Formulated by: Dr L Boominathan PhD

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CitationBoominathan, Insights into the treatment of Th2-mediated inflammation and allergic diseases: TGFβ alleviates Th2-medited inflammation and Allergy via up regulation of its target gene, 20/July/2014, 5.17 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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