Natural product-based Cardiac reprogramming and repair: Celastrol, a compound isolated from the herb “Thunder of God Vine,” promotes the generation of cardiomyocyte-like cells from differentiated cells by decreasing Snai1/Snail expression, 25/July/2014, 13.31

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  • A study from the Department of Clinical and Molecular Cardiovascular ResearchKeio University School of Medicine, Shinjuku-ku Tokyo, Japan;  Department of Cardiology, Keio University School of Medicine, Shinjuku-ku Tokyo, Japan;  and  JST CREST, Shinjuku-ku Tokyo, Japan has reported that “MiR-133 promotes cardiac reprogramming by directly repressing Snai1 and silencing …

  • This study was published in the 11 June 2014 EMBO Journal by Prof. Ieda M, Muraoka N and others from the Department of Clinical and Molecular Cardiovascular Research, Keio University School of Medicine, Shinjuku-ku Tokyo, Japan Department of Cardiology, Keio University School of Medicine, Shinjuku-ku Tokyo, Japan.
  • On the foundation of this interesting finding, Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports here that: Natural product-based Cardiac reprogramming and repair: Celastrol, a compound isolated from the herb “Thunder of God Vine,” promotes the generation of cardiomyocyte-like cells from differentiated cells by decreasing Snai1/Snail expression. This study suggests that Celastrol, by decreasing the expression of its target gene, it could increase the number of beating cardiomyocyte-like cells (iCMs).  Taken together, this study suggests that (1) pharmacological formulations encompassing “Celastrol or its analogues” can be used to increase the number of beating cardiomyocyte-like cells (iCMs); and (2) Celastrol analogues  can be used to promote cardiac repair.
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Idea Proposed/Formulated by: Dr L Boominathan Ph.D.

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To citeBoominathan, Natural product-based Cardiac reprogramming and repair: Celastrol, a compound isolated from the herb “Thunder of God Vine,” promotes the generation of cardiomyocyte-like cells from differentiated cells by decreasing Snai1/Snail expression, 25/July/2014, 13.33,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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