Natural product-based therapy for squamous cell carcinoma: Circilol (3′,4′,5-trihydroxy-6,7-dimethoxyflavone), a flavone isolated from Achillea fragrantissima, inhibits tumor-initiating cells and cancer stem cells via down regulation of Sox2, 12/July/2014, 9.41 am July 12, 2014
Anti-metastatic therapy: Metformin, the widely used drug in the treatment of NIDDM, inhibits invasion and metastasis via down regulation of ubiquitin specific peptidase 25, 13/July/2014, 5.36 am July 13, 2014
- A study from the Department of Developmental & Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, USA has reported that “Aging-like Phenotype and Defective Lineage Specification in SIRT1-Deleted Hematopoietic Stem and Progenitor Cells.“
- This study was published in the 5 July 2014 Stem cell Reports by Prof. Saghi Ghaffari, Pauline Rimmelé and others from the Department of Developmental & Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, USA.
- On the foundation of this interesting finding, Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports here that: Therapeutic insights into increasing the hematopoietic stem cell production: Stress-responsive protein p53 disrupts hematopoietic stem cell homeostasis via up regulation of its target gene. This study further suggests that p53, by increasing the expression of its target gene, it could alter the lineage specification of hematopoietic stem cells. Taken together, this study suggests that pharmacological formulations encompassing “p53 inhibitor” can be used to (1) augment hematopoietic stem cell production; (2) alter lineage specification; and (3) inhibit hematopoietic stem cell ageing.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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To cite: Boominathan, Therapeutic insights into increasing hematopoietic stem cell production: Stress responsive protein p53 disrupts hematopoietic stem cell homeostasis via up regulation of its target gene, 12/July/2014, 11.08 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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