Monthly Archives: August 2014

Natural product-based therapy for Bone disorders: Glabridin (GLA), found in the roots of liquorice, inhibits osteoporosis and bone metastasis via up regulation of its target gene, 1/September/2014, 5.21 am

A study from the Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA has reported that “miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2.” This study was published in the June 25, 2014 Nature  [I.F >42] by Prof. Wan Y, Krzeszinski and … Continue reading

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Natural product-based therapy for Cachexia: Celastrol, an antioxidant & anti-inflammatory drug from herb Thunder of God vine, inhibits skeletal muscle wasting via down regulation of E3 ubiquitin ligase TRAF6 , 31/August/2014, 5.09 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., Natural product-based therapy for Cachexia: Celastrol, an antioxidant & anti-inflammatory drug from herb Thunder of God vine, inhibits skeletal muscle wasting via down regulation of E3 ubiquitin ligase TRAF6, 1/September/2014, 5.10 am, Genome-2-Bio-Medicine Discovery … Continue reading

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Natural product-based therapy for Cachexia: Celastrol, an antioxidant & anti-inflammatory drug from herb Thunder of God vine, inhibits skeletal muscle wasting via down regulation of E3 ubiquitin ligase TRAF6 , 31/August/2014, 5.09 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., Natural product-based therapy for Cachexia: Celastrol, an antioxidant & anti-inflammatory drug from herb Thunder of God vine, inhibits skeletal muscle wasting via down regulation of E3 ubiquitin ligase TRAF6, 1/September/2014, 5.10 am, Genome-2-Bio-Medicine Discovery … Continue reading

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Mechanistic and therapeutic insights into rejuvenating immune cells in aged people: Androgen increases telomerase activity and inhibits senescence of human T cells via down regulation of its target gene, 1/September/2014, 05.03 am

A recent study from the Division of Infection and Immunity, University College London, London, UK shows that “The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells.” This study was published in the August 24  2014 Nature … Continue reading

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Therapeutic insights into the Regulation of Lipid distribution: GATA6 inhibits lipoprotein lipase via up regulation of its target gene, 1/September/2014, 4.48 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Therapeutic insights into the  Regulation of Lipid distribution: GATA6  inhibits lipoprotein lipase via up regulation of its target gene, 1/September/2014, 4.48 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Web: http://genomediscovery.org Courtesy: When you cite drop us a … Continue reading

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Mechanistic & Therapeutic insight into Metastatic progression: WASF3 promotes invasion and metastasis via down regulation of tumor suppressor p53 homolouge, TA-p73, 1/September/2014, 4.44 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., Mechanistic & Therapeutic insight into Metastatic progression: WASF3 promotes invasion and metastasis via down regulation of tumor suppressor p53 homolouge, TA-p73, 1/September/2014, 4.44 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Web: http://genomediscovery.org Courtesy: When you cite drop … Continue reading

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Mechanistic & Therapeutic insight into Metastatic progression: WASF3 promotes invasion and metastasis via down regulation of tumor suppressor p53 homolouge, TA-p73, 1/September/2014, 4.44 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., Mechanistic & Therapeutic insight into Metastatic progression: WASF3 promotes invasion and metastasis via down regulation of tumor suppressor p53 homolouge, TA-p73, 1/September/2014, 4.44 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Web: http://genomediscovery.org Courtesy: When you cite drop … Continue reading

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MiRNA-based therapy for Cancer: MiRNA-217 suppresses the expression of longevity-associated gene Sirtuin-1 via down regulation of its target gene, 1/September/2014, 4.37 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., MiRNA-based therapy for Cancer: MiRNA-217 suppresses the expression of longevity-associated gene Sirtuin-1 via down regulation of its target gene, 1/September/2014, 4.37 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Web: http://genomediscovery.org Courtesy: When you cite drop us a … Continue reading

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Insights into mechanisms that inhibit Cachexia: Snail/SNAI1 inhibits skeletal muscle wasting via down regualtion of E3 ubiquitin ligase TRAF6, 31/August/2014, 18.03

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., Insights into mechanisms that inhibit Cachexia: Snail/SNAI1 inhibits skeletal muscle wasting via down regualtion of E3 ubiquitin ligase TRAF6, 31/August/2014, 18.03, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Web: http://genomediscovery.org Courtesy: When you cite drop us a line at info@genomediscovery.org. * … Continue reading

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Anti-metastatic therapy: Tumor suppressor p53 inhibits tumor metastasis via down regulation of Lin28B, 31/August/2014, 18.00

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., Anti-metastatic therapy: Tumor suppressor p53 inhibits tumor metastasis via down regulation of Lin28B, 31/August/2014, 18.00, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Web: http://genomediscovery.org Courtesy: When you cite drop us a line at info@genomediscovery.org.  

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MiRNA-based therapy for DM: MiRNA-181b increases insulin cell mass and function via down regulation of its target gene, 31/August/2014, 16.21

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, MiRNA-based therapy for DM: MiRNA-181b increases insulin cell mass and function via down regulation of its target gene, 31/August/2014, 16.21, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Web: http://genomediscovery.org Courtesy: When you cite drop us a line at info@genomediscovery.org. Significance: This study suggests … Continue reading

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MiRNA-based treatment for Human Leukemia:MiRNA-139-5p inhibits acute leukemia via down regulation of Notch-regulated pro-oncogenic lncRNA LUNAR1, 31/August/2014, 16.17 am

A recent study from Howard Hughes Medical Institute, Center for Stem Cell Biology, NYU School of Medicine, 550 First Avenue, New York, USA has reported the role of Notch-regulated lncRNA LUNARI in Acute Leukemia. This study was published in the July 31  2014 Cell (I.F: >35; The number 1 … Continue reading

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Anti-metastasis therapy: Interleukin-6 promotes invasion and metastasis via down regulation of the tumor suppressor p53 homologue, p73 , 31/August/2014, 9.05 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., Anti-metastasis therapy:  Interleukin-6  promotes invasion and metastasis via down regulation of the tumor suppressor p53 homologue, p73 , 31/August/2014, 9.05 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Web: http://genomediscovery.org Courtesy: When you cite drop us a line at info@genomediscovery.org. Significance: This study … Continue reading

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Therapeutic insights into the treatment of spinal cord injury : RREB induces astrogliosis via up regulation of GFAP and c-myc, 31/August/2014, 6.00 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Therapeutic insights into the treatment of spinal cord injury : RREB induces astrogliosis via up regulation of  GFAP and c-myc, 31/August/2014, 5.59 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Web: http://genomediscovery.org Courtesy: When you cite drop us a line … Continue reading

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MiRNA-based Anti-metastasis therapy: MiRNA-7 increases the expression of tumor suppressor miRNA Let-7 via down regulation of its target gene, 31/August/2014, 5.57 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, MiRNA-based Anti-metastasis therapy: MiRNA-7 increases the expression of tumor suppressor miRNA Let-7 via down regulation of its target gene, 31/August/2014, 5.57 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Web: http://genomediscovery.org Courtesy: When you cite drop us a line … Continue reading

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MiRNA-based Regenerative therapy for T2D: MiRNA-380-5p promotes reprogramming of adult pancreatic ductal cells into α, δ, and β cells via up regulation of Ngn3, 31/August/2014, 5.43 am

A recent study from the Mammalian Genetics Laboratory, Cancer Research UK London Research Institute, Lincoln’s Inn Fields Laboratories, London, United Kingdom; and School of Medicine, King’s College London, London, United Kingdom shows that “Loss of Fbw7 Reprograms Adult Pancreatic Ductal Cells into α, … Continue reading

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Tumor suppressor miRNA-509-5p suppresses the expression of immortality gene telomerase via down regulation of its target gene, 31/August/2014, 5.28 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, MiRNA-based cancer stem cell therapeutics: Tumor suppressor miRNA-509-5p  suppresses the expression of immortality gene telomerase via down regulation of its target gene, 31/August/2014, 5.28 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Web: http://genomediscovery.org Courtesy: When you cite drop us … Continue reading

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Therapeutic insights into the treatment of DM: Tumor suppressor ARF suppresses the expression of an activator of insulin transcription, NeuroD1 via up regulation of its target gene 31/August/2014, 5.23 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Therapeutic insights into the treatment of DM: Tumor suppressor ARF suppresses the expression of an activator of insulin transcription, NeuroD1 via up regulation of its target gene 31/August/2014, 5.23 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Web: http://genomediscovery.org … Continue reading

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Mechanistic insights into tumor suppression: Tumor suppressor Menin (MEN1) inhibits tumor metastasis via down regulation of Lin28B, 30/August/2014, 21.53

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Mechanistic insights into tumor suppression: Tumor suppressor Menin (MEN1) inhibits tumor metastasis via down regulation of Lin28B, 30/August/2014, 21.53, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Web: http://genomediscovery.org Courtesy: When you cite drop us a line at info@genomediscovery.org. Significance: This study suggests … Continue reading

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Targeted molecular therapy for Myocardial Infarction: Tumor suppressor ING1b inhibits myocardial function after myocardial infarction via up regulation of its target gene, 30/August/2014, 9.35 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Targeted molecular therapy for Myocardial Infarction: Tumor suppressor ING1b inhibits  myocardial function after myocardial infarction via up regulation of its target gene, 30/August/2014, 9.35 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Web: http://genomediscovery.org Courtesy: When you cite drop us … Continue reading

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