Mechanistic and Therapeutic insights into the treatment of Human Leukemia: Tumor suppressor ARF inhibits acute leukemia via down regulation of Notch-regulated pro-oncogenic lncRNA LUNAR1, 16/August/2014, 09.05 am

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A recent study from Howard Hughes Medical Institute, Center for Stem Cell Biology, NYU School of Medicine, 550 First Avenue, New York, USA has reported the role of Notch-regulated lncRNA LUNARI in Acute Leukemia. This study was published in the July 31  2014 Cell (The number 1 journal in basic biology) by Prof  Iannis Aifantis, Thomas Trimarchi and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Mechanistic and Therapeutic insights into the treatment of Human Leukemia: Tumor suppressor ARF inhibits acute leukemia via down regulation of Notch-regulated pro-oncogenic lncRNA LUNAR1This study suggests that ARF, by decreasing the expression of  Notch-1, lncRNA LUNAR1 and IGF1R mRNA, it may inhibit acute leukemia. Together, this study suggests that pharmacological formulations encompassing  ARF activators” may be used to treat patients (with no mutation or deletion in the ARF gene) suffering from leukemia.

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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To citeBoominathan, Mechanistic and Therapeutic insights into the treatment of Human Leukemia: Tumor suppressor ARF inhibits acute leukemia via down regulation of Notch-regulated pro-oncogenic lncRNA LUNAR1., 16/August/2014,  09.05 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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