A recent study from the Mammalian Genetics Laboratory, Cancer Research UK London Research Institute, Lincoln’s Inn Fields Laboratories, London, United Kingdom; and School of Medicine, King’s College London, London, United Kingdom shows that “Loss of Fbw7 Reprograms Adult Pancreatic Ductal Cells into α, δ, and β Cells.” This study was published in the August 7 2014 Cell Stem Cell by Prof Axel Behrens, Rocio Sancho, and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Mechanistic and Therapeutic insights into why prolonged stress promotes the development of NIDDM/T2D: Adenocorticotrophic hormone (ACTH) decreases reprogramming of adult pancreatic ductal cells into α, δ, and β cells via down regulation of Ngn3. This study suggests that ACTH, by decreasing the expression of Ngn3 in adult pancreatic ductal cells, it may inhibit the reprograming of adult pancreatic ductal cells into β cells. Thereby, it may decrease the expression of Ngn3, and reduce insulin secretion and insulin sensitivity. Together, this study suggests that pharmacological formulations encompassing“ACTH inhibitors” may be used to treat stress-induced NIDMM.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/To cite: Boominathan, Mechanistic and Therapeutic insights into why prolonged stress promotes the development of NIDDM/T2D: Adenocorticotrophic hormone (ACTH) decreases reprogramming of adult pancreatic ductal cells into α, δ, and β cells via down regulation of Ngn3, 17/August/2014, 19.41, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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