MiRNA-based Regenerative therapy for T2D: c-Myc promotes reprogramming of adult pancreatic ductal cells into α, δ, and β cells via up regulation of Ngn3, 16/August/2014, 19.41

Targeted molecular therapy for Myocardial Infarction: The RNA-binding protein PCBP2 improves myocardial function after myocardial infarction via down regulation of its target gene, 16/August/2014, 19.28
August 16, 2014
Molecular therapy for Myocardial infarction: Cell cycle-regulated protein E2F3 promotes myocardial survival post myocardial infarction via up regulation of aldehyde dehydrogenase 2, 17/August/2014, 5.51 am
August 17, 2014
Show all

A recent study from the Mammalian Genetics Laboratory, Cancer Research UK London Research Institute, Lincoln’s Inn Fields Laboratories, London, United Kingdom; and School of Medicine, King’s College London, London, United Kingdom shows that “Loss of Fbw7 Reprograms Adult Pancreatic Ductal Cells into α, δ, and β Cells.” This study was published in the August 7  2014 Cell Stem Cell by Prof Axel Behrens, Rocio Sancho, and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: MiRNA-based Regenerative therapy for T2D: c-Myc promotes  reprogramming of adult pancreatic ductal cells into α, δ, and β cells via up regulation of Ngn3. This study suggests that c-Mycby increasing the expression of Ngn3 in adult pancreatic ductal cells, it may reprogram adult pancreatic ductal cells into β cells.  Thereby, it may induce the expression of Ngn3, increase insulin secretion and inhibit insulin resistance. Together, this study suggests that pharmacological formulations encompassing“c-Myc activators” may be used to regenerate  β cells in T2D patients

Idea Proposed/Formulated byDr L Boominathan Ph.D.

Web: http://genomediscovery.org

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

To citeBoominathan, MiRNA-based Regenerative therapy for T2D: c-Myc promotes  reprogramming of adult pancreatic ductal cells into α, δ, and β cells via up regulation of Ngn3, 16/August/2014, 19.42,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite drop us a line at info@genomediscovery.org

* Research cooperation

Comments are closed.