Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, Therapeutic insights into metabolism, ageing and longevity: OncomiR-17-92 increases the expression of longevity-associated gene product sirtuin-1 via up regulation of its target gene, 29/August/2014, 10.45 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Significance: This study suggests that oncogenic miRNA-17-92, by suppressing the expression of its target gene, it may increase the expression of longevity gene Sirtuin-1. Furthermore, this study suggests that pharmacological formulations encompassing ” miR-17-92 activator” may (1) increase the life expectancy of an individual; (2) increase insulin cell mass and insulin sensitivity; and (3) deaccelerate ageing process.