Monthly Archives: September 2014

Natural product-based therapy for Cancer: Berberine inhibits tumor cell proliferation via down regulation of Superoxide dismutase 1 (SOD1), 30/September/2014, 12.38 pm

The 1989 Nobel prize winner in Physiology/Medicine Prof. Varmus Harold E, Somwar R and others from High Throughput Screening Core Facility, and Organic Synthesis Core Facility, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA; and US National Cancer Institute, USA has published a research paper in the 27 September 2011 Proc Natl … Continue reading

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Addressing Nobel laureate Bishop JM’s conundrum (c-MYC suppresses cancer metastasis): Does p53 function as a metastasis promoter in certain cellular contexts by increasing the expression of αv and β3 integrin subunits?, 30/September/2014, 9.17 am

The 1989 Nobel prize winner in Physiology/Medicine, Prof. Bishop JM, Liu H and others from G.W. Hooper Foundation, University of California at San Francisco, San Francisco, California 94143, USA has published a research paper in the 13 May 2012 Nature Cell Biology (I.F: 20.058) stating that “MYC suppresses cancer metastasis by direct transcriptional silencing of … Continue reading

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Molecular therapy for Human Cancer: MyoD suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) via up regulation of its target gene, 30/September/2014, 8.17 am

The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 Nature (492(7428):285-9; I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.”  This study provides mechanistic insights into how TPP1 regulates telomerase function. In connection with this finding, Dr Boominathan, … Continue reading

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MiRNA-based cancer therapeutics: MiRNA-141 increases the expression of tumor suppressor p53 and its homolouge p73 via down regulation of its target gene, 30/September/2014, 08.00 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, MiRNA-based cancer therapeutics: MiRNA-141 increases the expression of tumor suppressor p53 and its homolouge p73 via down regulation of its target gene, 30/September/2014, 08.00 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Web: http://genomediscovery.org Courtesy: When you cite drop … Continue reading

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MiRNA-based Anti-Ageing therapy: MiRNA-492 increases the expression of immortality gene telomerase via down regulation of its target gene, 30/September/2014, 07.02 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, MiRNA-based Anti-Ageing therapy: MiRNA-492 increases the expression of immortality gene telomerase via down regulation of its target gene, 30/September/2014, 07.02 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Web: http://genomediscovery.org Courtesy: When you cite drop us a line … Continue reading

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Therapeutic insights into the treatment of amyotrophic lateral sclerosis: Stress induced gene product p53 aggravates amyotrophic lateral sclerosis via down regulation of HSF1/HSP70i chaperone, 29/September/2014, 06.28 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Therapeutic insights into the treatment of  amyotrophic lateral sclerosis:  Stress induced gene product p53 aggravates amyotrophic lateral sclerosis via down regulation of HSF1/HSP70i chaperone, 30/September/2014, 06.28 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Web: http://genomediscovery.org Courtesy: When you cite drop us … Continue reading

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Mechanistic insights into tumorigenesis: SNAI2 increases the expression of stem cell protein Sox2 via up regulation of its target gene, 30/September/2014, 04.58 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Mechanistic insights into tumorigenesis: SNAI2 increases the expression of stem cell protein Sox2 via up regulation of its target gene, 30/September/2014, 04.57 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Web: http://genomediscovery.org Courtesy: When you cite drop us a line … Continue reading

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Therapeutic insights into the treatment of Fibrosis: SMAD7 inhibits pulmonary fibrosis via up regulation of its target gene, 30/September/2014, 04.54 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Therapeutic insights into the treatment of Fibrosis: SMAD7 inhibits pulmonary fibrosis via up regulation of its  target gene, 30/September/2014, 04.54 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Web: http://genomediscovery.org Courtesy: When you cite drop us a line at info@genomediscovery.org Significance: This study … Continue reading

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Natural product-based therapy for increased Male longevity: Silvestrol, a compound isolated from the fruits of Aglaia foveolata, increases male life span via down regulation of its target gene, 30/September/2014, 04.50 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Natural product-based therapy for increased Male  longevity:  Silvestrol, a compound isolated from the fruits of Aglaia foveolata,  increases male life span via down regulation of its target gene, 30/September/2014, 04.50 am,  Genome-2-Bio-Medicine Discovery … Continue reading

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Molecular therapy for Psoriasis: p53 decreases psoriasiform skin inflammation via down regulation of its target gene, 30/September/2014, 04.46 am

A recent study from the Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts; Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA; and Institute for Biomedical Research, University College London, London, UK shows that “Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation.” This study was published in … Continue reading

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Natural product-based anti-metastasis therapy: Rhamnetin, an O-methylated flavonol isolated from cloves, suppresses the expression of transcription coactivator peroxisome proliferator-activated receptor gamma, coactivator 1 alpha and inhibits metastasis via up regulation of its target gene, 29/September/2014, 07.48 am

A study from the Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA shows that Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis. This study … Continue reading

Comments Off on Natural product-based anti-metastasis therapy: Rhamnetin, an O-methylated flavonol isolated from cloves, suppresses the expression of transcription coactivator peroxisome proliferator-activated receptor gamma, coactivator 1 alpha and inhibits metastasis via up regulation of its target gene, 29/September/2014, 07.48 am

Mechanistic insights into tumorigenesis: SNAI2 increases the expression of stem cell protein Oct-4 via up regulation of its target gene, 29/September/2014, 07.04 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Mechanistic insights into tumorigenesis: SNAI2 increases the expression of stem cell protein Oct-4 via up regulation of its target gene, 29/September/2014, 07.04 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Web: http://genomediscovery.org Courtesy: When you cite drop us a line … Continue reading

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Natural product-based therapy for tumor suppression: Sulfuretin, an anti-inflammatory agent isolated from Rhus verniciflua, suppresses the expression of pro-proliferative protein Rab18/WARBM3 via up regulation of its target gene, 29/September/2014, 07.00 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Natural product-based therapy for tumor suppression: Sulfuretin, an anti-inflammatory agent isolated from Rhus verniciflua, suppresses the expression of pro-proliferative protein Rab18/WARBM3 via up regulation of its target gene, 29/September/2014, 07.00 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Web: http://genomediscovery.org … Continue reading

Comments Off on Natural product-based therapy for tumor suppression: Sulfuretin, an anti-inflammatory agent isolated from Rhus verniciflua, suppresses the expression of pro-proliferative protein Rab18/WARBM3 via up regulation of its target gene, 29/September/2014, 07.00 am

Natural product-based therapy for amyotrophic lateral sclerosis: Fisetin, a flavonoid enriched in strawberries, Mangoes and Cucumber, ameliorates amyotrophic lateral sclerosis via up regulation of HSF1/HSP70i chaperone, 29/September/2014, 06.08 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Natural product-based therapy for amyotrophic lateral sclerosis:  Fisetin, a flavonoid enriched in strawberries, Mangoes and Cucumber, ameliorates amyotrophic lateral sclerosis via up regulation of HSF1/HSP70i chaperone, 29/September/2014, 06.08 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Web: http://genomediscovery.org Courtesy: When you cite drop … Continue reading

Comments Off on Natural product-based therapy for amyotrophic lateral sclerosis: Fisetin, a flavonoid enriched in strawberries, Mangoes and Cucumber, ameliorates amyotrophic lateral sclerosis via up regulation of HSF1/HSP70i chaperone, 29/September/2014, 06.08 am

MiRNA-based Regenerative therapy for DM: MIRNA-492 increases insulin-secreting cell mass and function via up regulation of its target genes, 29/September/2014, 05.47 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, MiRNA-based Regenerative therapy for DM: MIRNA-492 increases insulin-secreting cell mass and function via up regulation of its target genes, 29/September/2014, 05.50 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Web: http://genomediscovery.org Courtesy: When you cite drop us a line at info@genomediscovery.org * Research … Continue reading

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Therapeutic insights into increasing HDL levels in Cardiovascular patients: Protein Arginine N-Methyltransferase (PRMT4) increases HDL-C via up regualtion of its target gene, 29/September/2014, 05.39 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Therapeutic insights into increasing HDL levels in Cardiovascular patients: Protein Arginine N-Methyltransferase (PRMT4) increases HDL-C via up regualtion of its target gene, 29/September/2014, 05.39 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Web: http://genomediscovery.org Courtesy: When you cite drop us … Continue reading

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Therapeutic insights into the treatment of Fibrosis: GATA6 inhibits pulmonary fibrosis via up regulation of its target gene, 29/September/2014, 05.30 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Therapeutic insights into the treatment of Fibrosis: GATA6 inhibits pulmonary fibrosis via up regulation of its  target gene, 29/September/2014, 05.30 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Web: http://genomediscovery.org Courtesy: When you cite drop us a line at info@genomediscovery.org Significance: This study … Continue reading

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Mechanistic insights into the Regulation of glycolytic pathway in Immune cells: NFKB decreases the expression of a number of genes in the glycolysis pathway, 29/September/2014, 05.26 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Mechanistic insights into the Regulation of glycolytic pathway in Immune cells: NFKB decreases the expression of a number of genes in the glycolysis pathway, 29/September/2014, 05.26 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Web: http://genomediscovery.org Courtesy: When you cite drop … Continue reading

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Molecular therapy for Psoriasis: BMP4 decreases psoriasiform skin inflammation via down regulation of its target gene, 29/September/2014, 05.18 am

A recent study from the Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts; Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA; and Institute for Biomedical Research, University College London, London, UK shows that “Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation.” This study was published in … Continue reading

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MiRNA-based therapy for Human Cancer: MiRNA-1 suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) via up regulation of its target gene, 29/September/2014, 5.13 am

The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 Nature (492(7428):285-9; I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.”  This study provides mechanistic insights into how TPP1 regulates telomerase function. In connection with this finding, Dr Boominathan, … Continue reading

Comments Off on MiRNA-based therapy for Human Cancer: MiRNA-1 suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) via up regulation of its target gene, 29/September/2014, 5.13 am