Anti-miRNA based therapy for T2D: Over-expression of Stress-responsive MiRNA-449a promotes gluconeogenesis and hyperglycemia via down regulation of Cyclin D1, Genome-2-Bio-Medicine Discovery center (GBMD), 09/September/2014, 6.10 am

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A study from the Department of Cancer Biology, Dana-Farber Cancer Institute;  Department of Cell Biology, Harvard Medical School, USA shows that Cyclin D1–Cdk4 controls glucose metabolism independently of cell cycle progression.”

This study was published in the June 26, 2014 Nature [I.F >35] by Prof. Puigserver and others from the Department of Cancer Biology, Dana-Farber Cancer Institute;  Department of Cell Biology, Harvard Medical School, USA.

On the foundation of this interesting finding, Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports here that: Anti-miRNA based therapy for T2D: Over-expression of Stress-responsive MiRNA-449a promotes gluconeogenesis and hyperglycemia via down regulation of Cyclin D1.  This study suggests that MiRNA-449a, by down regulating its target gene, it may promote  gluconeogenesis and hyperglycemia. Together, this study suggests that pharmacological formulations encompassing “antagomiR-449a or small molecule inhibitors of miRNA-449a”   may be used in the treatment of NIDDM.

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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To citeBoominathan, L., Anti-miRNA based therapy for T2D: Over-expression of Stress-responsive MiRNA-449a promotes gluconeogenesis and hyperglycemia via down regulation of Cyclin D1, Genome-2-Bio-Medicine Discovery center (GBMD), 09/September/2014, 6.10 am.,  http://genomediscovery.org

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