A recent study from the Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California, USA shows that “Aldehyde dehydrogenase-2 regulates nociception in rodent models of acute inflammatory pain.” This study was published in the August 27 2014 Sci Transl Med by Prof D. Mochly-Rosen, and others.
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Insights into the development of cardiac-safe analgesics: PCBP2 inhibits inflammatory pain stimuli via up regulation of aldehyde dehydrogenase 2. PCBP2, by suppressing the expression of its target gene, it may decrease the accumulation of aldehyde (a pain-stimulating agent). Together, this study suggests that pharmacological formulations encompassing “PCBP2 activators” may be used to inhibit inflammatory pain stimuli.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, Insights into the development of cardiac-safe analgesics: PCBP2 inhibits inflammatory pain stimuli via up regulation of aldehyde dehydrogenase 2, 4/September/2014, 11.38 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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