Vitamin-based therapy for DM: ATRA (a derivative of Vitamin-A) increases the expression of a positive regulator of insulin transcription, NeuroD1 via down regulation of its target gene, 3/September/2014, 05.08 am
Insights into the development of cardiac-safe analgesics: Snail/SNAI1 inhibits inflammatory pain stimuli via up regulation of aldehyde dehydrogenase 2, 2/September/2014, 13.03
September 2, 2014Natural product-based therapy for Cancer: Resveratrol increases the expression of tumor suppressor LKB1 via down regulation of its target gene, 3/September/2014, 05.24 am
September 2, 2014Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, Vitamin-based therapy for DM: ATRA (a derivative of Vitamin-A) increases the expression of a positive regulator of insulin transcription, NeuroD1 via down regulation of its target gene, 3/September/2014, 05.08 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Significance: It has been known for years that ATRA inhibits insulin resistance. However, the mechanistic basis remains far from clear. This study suggests, for the first time, that ATRA, by increasing the expression of its target gene, it may decrease the expression of a number of stress responsive proteins. Thereby, it may increase the expression of an activator of insulin transcription, NeuroD1. Given this, physicians may consider prescribing “ATRA” to treat DM.
