Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, Mechanism of tumorigenesis: Stem cell protein Oct-4 decreases the expression of tumor suppressor p53 homologue p73 via up regulation of its target gene, 25/September/2014, 07.04 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Significance: This study suggests that Oct-4, by increasing the expression of its target gene, it may decrease the expression of tumor suppressor p53 homologue p73. Thereby, it may function as a tumorigenesis. Thus, pharmacological formulations encompassing “Oct-4 or its inhibitor” may be used to inhibit tumor progression.
* Research cooperation