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Idea Proposed/Formulated byDr L Boominathan Ph.D.

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CitationBoominathan,  Mechanism of tumorigenesis:  Stem cell protein Oct-4 decreases the expression of tumor suppressor p53 homologue p73 via up regulation of its target gene, 25/September/2014, 07.04 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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Significance: This study suggests that Oct-4, by increasing the expression of its target gene, it may decrease the expression of tumor suppressor p53 homologue p73. Thereby, it may function as a tumorigenesis. Thus, pharmacological formulations encompassing “Oct-4 or its inhibitor” may be used to inhibit tumor progression. 

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