AntagomiR-based Regenerative stem cell therapy for Myocardial Infarction: MiRNA-134 inhibits myocardial function after myocardial infarction via down regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 19/September/2014, 12.30 pm

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A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the March 7  2013 issue of Nature  by Prof Dimmler, Boon, and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: AntagomiR-based Regenerative stem cell therapy for Myocardial Infarction: MiRNA-134 inhibits myocardial function after myocardial infarction via  down regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10). By decreasing the expression of miR-134 in cardiomyocytes, one may prevent ageing-associated decline in cardiac function.  Together, this study suggests that pharmacological formulations encompassing “miR-134 suppressors” may be used to improve cardiac function after myocardial infarction.

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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To citeBoominathan,  AntagomiR-based Regenerative stem cell therapy for Myocardial Infarction: MiRNA-134 inhibits myocardial function after myocardial infarction via  down regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 19/September/2014,  12.31 pm,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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