Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, Therapeutic insights into increasing the HbF levels: 17α-E2 (an Estrogen derivative) increases fetal HbF levels via down regulation of its target gene, 24/September/2014, 09.38 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Significance: This study suggests that 17α-E2, by down regulating the expression of its target gene, it may increase the levels of HbF. Thus, pharmacological formulations encompassing “17α-E2 or its analogues” may be used to treat: (1) Sickle cell disease ; (2) β-thalassemias; and (3) disease conditions that has lower levels of HbF.
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