Insights into the development of cardiac-safe analgesics: Snail/SNAI1 inhibits inflammatory pain stimuli via up regulation of aldehyde dehydrogenase 2, 2/September/2014, 13.03

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A recent study from the Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California, USA shows that “Aldehyde dehydrogenase-2 regulates nociception in rodent models of acute inflammatory pain.  This study was published in the August 27 2014  Sci Transl Med   by Prof D. Mochly-Rosenand others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:  Insights into the development of cardiac-safe analgesics:  Snail/SNAI1 inhibits inflammatory pain stimuli via up regulation of  aldehyde dehydrogenase 2.  Snail/SNAI1, by suppressing the expression of its target gene, it may decrease the accumulation of aldehyde (a pain-stimulating agent). Together, this study suggests that pharmacological formulations encompassing Snail/SNAI1  activators may be used to inhibit inflammatory pain stimuli. 

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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CitationBoominathan, Insights into the development of cardiac-safe analgesics:  Snail/SNAI1 inhibits inflammatory pain stimuli via up regulation of  aldehyde dehydrogenase 2 2/September/2014,  13.03,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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