Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, Vitamin-based therapy for DM: 1,25-dihydroxyvitamin D3 increases the expression of a positive regulator of insulin transcription, NeuroD1 via down regulation of its target gene, 2/September/2014, 06.23 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Significance: It has been known for years that Vitamin-D3 inhibits insulin resistance. However, the mechanistic basis of which remains largely unknown. This study suggests, for the first time, that 1,25-dihydroxyvitamin D3, by increasing the expression of its target gene, it may decrease the expression of a number of stress responsive proteins. Thereby, it may increase the expression of an activator of insulin transcription, NeuroD1. Given the mechanistic basis, physicians may consider prescribing “1,25-dihydroxyvitamin D3“ to treat DM.