Monthly Archives: October 2014

MiRNA-based Regenerative therapy for DM: MiRNA-29c increases insulin-secreting cell mass and function via up regulation of its target genes, 31/October/2014, 7.00 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, MiRNA-based Regenerative therapy for DM: MiRNA-29c increases insulin-secreting cell mass and function via up regulation of its target genes, 31/October/2014, 7.00 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance: This study suggests, for the first time, that MiRNA-29c, by decreasing the … Continue reading

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Natural product-based therapy for Cancer: Phloretin decreases glutathione levels, increases reactive oxygen species levels and inhibits cancer cell proliferation via up regulation of its target gene, 31/October/2014, 5.59 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Natural product-based therapy for Cancer: Phloretin  decreases glutathione levels, increases reactive oxygen species levels and inhibits cancer cell proliferation via up regulation of its target gene, 31/October/2014, 5.59 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org … Continue reading

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Therapeutic Insights into the Regulation of fetus growth: Stress induced gene miR-204 inhibits fetal growth via down regulation of its target gene, 31/October/2014, 5.53 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org To cite: Boominathan,  Therapeutic Insights into the Regulation of fetus growth: Stress induced gene miR-204 inhibits fetal growth via down regulation of its target gene, 31/October/2014, 5.53 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you cite drop us a line … Continue reading

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Anti-metastasis therapy: Angiopoietin-like protein 1 suppresses the expression of SMAD3 via up regulation of its target gene, 31/October/2014, 5.43 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Citation: Boominathan, L., Anti-metastasis therapy: Angiopoietin-like protein 1 suppresses the expression of SMAD3 via up regulation of its target gene, 31/October/2014, 5.43 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Significance: This study suggests that Angiopoietin-like protein 1, by increasing the expression of its … Continue reading

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Chemopreventive therapy against metastatic cancer: Germinated brown rice (GBR) inhibits cancer cell metastasis via down regulation of Epithelial to Mesenchymal Transition (EMT) promoter ZEB2, 31/October/2014, 5.37 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Chemopreventive therapy against metastatic cancer: Germinated brown rice (GBR) inhibits cancer cell metastasis via down regulation of Epithelial to Mesenchymal Transition (EMT) promoter ZEB2, 31/October/2014, 5.38 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you cite drop … Continue reading

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Chemopreventive therapy against Human Cancer: Zanthoxylum piperitum DC fruit ethanol extract (ZPE) inhibits tumor cell proliferation via down regulation of Superoxide dismutase 1 (SOD1), 31/October/2014, 5.31 am

The 1989 Nobel prize winner in Physiology/Medicine Prof. Varmus Harold E, Somwar R and others from High Throughput Screening Core Facility, and Organic Synthesis Core Facility, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA; and the US National Cancer Institute, USA has published a research paper in the 27 September 2011 issue of Proc Natl Acad Sci … Continue reading

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MiRNA-based therapy for Cancer: Curcumin, the major component of turmeric, inhibits proliferation and promotes senescence through up regulation of tumor suppressor LKB1, 31/October/2014, 05.23 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Citation: Boominathan, MiRNA-based therapy for Cancer: Curcumin, the major component of turmeric, inhibits proliferation and promotes senescence through up regulation of tumor suppressor LKB1, 31/October/2014, 05.23 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance: This study suggests that Curcumin, by decreasing the … Continue reading

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Small RNA-based Life-extension therapy for Males: MiRNA-375 increases male longevity via up regulation of its target gene, 19/October/2014, 5.17 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., Small RNA-based Life-extension therapy for Males: MiRNA-375 increases male longevity via up regulation of its target gene, 19/October/2014, 5.18 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance:  This study suggests  that MiRNA-375, by increasing the expression of its … Continue reading

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Natural product-based therapy for traumatic brain injury (TBI): IL-6 alleviates apoptosis of neuronal cells after traumatic brain injury via up regulation of its target gene, 31/October/2014, 5.10 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Citation: Boominathan, Natural product-based therapy for traumatic brain injury (TBI):  IL-6  alleviates apoptosis of neuronal cells after traumatic brain injury via up regulation of its target gene, 31/October/2014, 5.10 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Significance: This study suggests … Continue reading

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Natural product-based therapy for Cancer: Fermented guava leaf extract increases the expression of the tumor suppressor TPM1 via down regulation of its target gene, 31/October/2014, 5.06 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Natural product-based therapy for Cancer: Fermented guava leaf extract  increases the expression of the tumor suppressor TPM1 via down regulation of its target gene, 31/October/2014, 5.06 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you cite drop … Continue reading

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Small RNA-based therapy for Myocardial Infarction: MiRNA-150 improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 31/October/2014, 05.01 am

A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Small … Continue reading

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Natural product-based therapy for Cancer: N-arachidonoyl ethanolamine decreases glutathione levels, increases reactive oxygen species levels and inhibits cancer cell proliferation via up regulation of its target gene, 30/October/2014, 10.16 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Natural product-based therapy for Cancer: N-arachidonoyl ethanolamine  decreases glutathione levels, increases reactive oxygen species levels and inhibits cancer cell proliferation via up regulation of its target gene, 30/October/2014, 10.16 am,  Genome-2-Bio-Medicine Discovery … Continue reading

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Therapeutic Insights into the Regulation of fetus growth: Stress induced gene miR-183 inhibits fetal growth via down regulation of its target gene, 30/October/2014, 9.55 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org To cite: Boominathan,  Therapeutic Insights into the Regulation of fetus growth: Stress induced gene miR-183 inhibits fetal growth via down regulation of its target gene, 30/October/2014, 9.58 am Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you cite drop us a … Continue reading

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Natural product-based therapy for Cancer: Fermented guava leaf extract increases the expression of the tumor suppressor KRIT1/CCM1 via down regulation of its target gene, 30/October/2014,9.51 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Natural product-based therapy for Cancer: Fermented guava leaf extract  increases the expression of the tumor suppressor KRIT1/CCM1 via down regulation of its target gene, 30/October/2014,9.51 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you cite drop us a … Continue reading

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Chemopreventive therapy against multidrug resistance in cancer: Germinated brown rice (GBR) extract decreases the expression of P-glycoprotein mediated multidrug resistance gene and inhibits metastasis via down regulation of its target gene, 30/October/2014, 8.21 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Chemopreventive therapy against multidrug resistance in cancer:  Germinated brown rice (GBR) extract decreases the expression of P-glycoprotein mediated multidrug resistance gene and inhibits metastasis  via down regulation of its target gene, 30/October/2014, … Continue reading

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Anti-metastasis therapy: Angiopoietin-like protein 1 suppresses the expression of CTGF via up regulation of its target gene, 30/October/2014, 8.07 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Citation: Boominathan, L., Anti-metastasis therapy: Angiopoietin-like protein 1 suppresses the expression of CTGF via up regulation of its target gene, 30/October/2014, 8.07 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Significance: This study suggests that Angiopoietin-like protein 1, by increasing the expression of … Continue reading

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Therapeutic insights into increasing the life span of an Individual: MiRNA-150 increases male life span via down regulation of its target gene, 30/October/2014, 22.34

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org To cite: Boominathan, Therapeutic insights into increasing the life span of an Individual: MiRNA-150 increases male life span via down regulation of its target gene, 30/October/2014, 22.34,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Courtesy: When you cite drop us a line … Continue reading

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Natural product-based therapy for traumatic brain injury (TBI): NFKB alleviates apoptosis of neuronal cells after traumatic brain injury via up regulation of its target gene, 30/October/2014, 7.20 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Citation: Boominathan, Natural product-based therapy for traumatic brain injury (TBI):  NFKB  alleviates apoptosis of neuronal cells after traumatic brain injury via up regulation of its target gene, 30/October/2014, 7.20 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Significance: This study suggests … Continue reading

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Chemopreventive therapy against Human Cancer: A. officinarum ethanol extract (AOE) inhibits tumor cell proliferation via down regulation of Superoxide dismutase 1 (SOD1), 30/October/2014, 7.13 am

The 1989 Nobel prize winner in Physiology/Medicine Prof. Varmus Harold E, Somwar R and others from High Throughput Screening Core Facility, and Organic Synthesis Core Facility, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA; and the US National Cancer Institute, USA has published a research paper in the 27 September 2011 issue of Proc Natl Acad Sci … Continue reading

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MiRNA-based therapy for Cancer: MiRNA-22 inhibits proliferation and promotes senescence through up regulation of tumor suppressor LKB1, 30/October/2014, 07.08 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Citation: Boominathan, MiRNA-based therapy for Cancer: MiRNA-22 inhibits proliferation and promotes senescence through up regulation of tumor suppressor LKB1, 30/October/2014, 07.08 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance: This study suggests that tumor suppressor MiRNA-22, by decreasing the expression of its target … Continue reading

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