Mechanistic and Therapeutic insights into Cardiac reprogramming: TAp63 promotes the generation of cardiomyocyte-like cells from differentiated cells by decreasing Snai1/Snail expression, 21/October/2014, 8.13 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Web: http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ To cite: Boominathan, Mechanistic and Therapeutic insights into Cardiac reprogramming: TAp63 promotes the generation of cardiomyocyte-like cells from differentiated cells by decreasing Snai1/Snail expression, 21/October/2014, 8.13 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance: This study suggests that TAp63, by increasing the expression of its target gene, it could increase the number of beating cardiomyocyte-like cells (iCMs).  Taken […]

Natural product-based therapy for cancer: Curcumin, the major component of turmeric, suppresses the expression of Notch1 and Notch2 via up regulation of its target gene, 21/October/2014, 7.51 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Citation: Boominathan, Natural product-based therapy for cancer: Curcumin, the major component of turmeric, suppresses the expression of Notch1 and Notch2 via up regulation of its target gene, 21/October/2014, 7.51 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Significance: This study suggests that Curcumin, by increasing the expression of its target gene, it may suppress the expression of Notch1 and Notch2.  Thus, pharmacological […]

Physiological and Pathological mechanisms that control glycolysis: SNAI inhibits glycolysis and cancer progression via down regulation of PDK1, 21/October/2014, 07.03 am

A recent study from the Institute for Cancer Research and CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Biology, School of Life Science, University of Science and Technology of China, Hefei 230027, China shows that “Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1.” This study was published in the 10 October issue of 2014 Nature Communications by Prof Zhang, Ma, and others. On the foundation of this interesting finding, Dr […]

Therapeutic insights into increasing the life expectancy of Males: CDX2 protein increases male longevity via up regulation of its target gene, 21/October/2014, 6.51 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., Therapeutic insights into increasing the life expectancy of Males: CDX2 protein increases male longevity via up regulation of its target gene, 21/October/2014, 6.51 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance:  This study suggests, for the first time,  that CDX2 protein, by increasing the expression of its target gene, it may increase […]