Anti-cancer stem cell therapeutics: Campothecin (CPT) inhibits mammary cancer stem cell proliferation via down regulation of Wnt receptor FZD7, 01/October/2014, 14.50

Natural product-based anti-metastasis therapy: Luteolin, a flavone with an antioxidant and anti-inflammatory activity, suppresses the expression of transcription coactivator peroxisome proliferator-activated receptor gamma, coactivator 1 alpha and inhibits metastasis via up regulation of its target gene, 01/October/2014, 11.19 am
October 1, 2014
MiRNA-based therapy for Psoriasis: MiRNA-145 aggravates psoriasiform skin inflammation via down regulation of its target gene, 02/October/2014, 08.31 am
October 2, 2014
Show all

A study from the Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA shows that ΔNp63 promotes stem cell activity in mammary gland development and basal-like breast cancer by enhancing Fzd7 expression and Wnt signalling.”

This study was published in the September issue of 2014 Nature Cell Biology (I.F: 20.085) by Dr. Kang Y, Rumela Chakrabarti  [I.F > 20.058] and others from the Princeton University, New Jersey 08544, USA

On the foundation of this interesting finding, Dr L Boominathan, Director-cum-chief Scientist of GBMDreports here that: Anti-cancer stem cell  therapeutics: Campothecin (CPT) inhibits mammary cancer stem cell proliferation via down regulation of Wnt receptor FZD7 This study may suggest that Campothecin, by up regulating its target gene, it may inhibit the Wnt pathway. Together, this study suggests that pharmacological formulations encompassing Campothecin  or its analogues” can be used to inhibit mammary tumor initiating cells.

Idea Proposed/Formulated byDr L Boominathan Ph.D.

Web: http://genomediscovery.org

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

To citeBoominathan, L., Anti-cancer stem cell  therapeutics: Campothecin (CPT) inhibits mammary cancer stem cell proliferation via down regulation of Wnt receptor FZD7, 01/October/2014, 14.50, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite drop us a line at info@genomediscovery.org

* Research cooperation

Comments are closed.