Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Citation: Boominathan, L., Anti-MiRNA-based therapy for Dementias: Stress-induced miRNA-520c inhibits memory consolidation via down regulation of memory genes LIMK and CREB1, 16/October/2014, 6.57 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
Significance: This study has elucidated the mechanism by Stress-induced MiRNA-520c inhibits memory consolidation. MIRNA-520c, by suppressing the expression of its target gene, it could decrease the expression of memory genes such as LIMK and CREB1. This result suggests that, by suppressing the expression of miR-128, one could increase the expression of memory consolidation genes. Thus, pharmacological formulations encompassing “MIRNA-520c inhibitors” can be used to treat patients suffering from dementias.
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