Anti-cancer Stem cell therapeutics: TPA (12-O-Tetradecanoylphorbol-13-Acetate) inhibits mammary cancer stem cell proliferation via down regulation of Wnt receptor FZD7, 04/October/2014

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A study from the Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA shows that ΔNp63 promotes stem cell activity in mammary gland development and basal-like breast cancer by enhancing Fzd7 expression and Wnt signalling.”

This study was published in the September issue of 2014 Nature Cell Biology (I.F: 20.085) by Dr. Kang Y, Rumela Chakrabarti  [I.F > 20.058] and others from the Princeton University, New Jersey 08544, USA

On the foundation of this interesting finding, Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports here that: Anti-cancer Stem cell  therapeutics: TPA (12-O-Tetradecanoylphorbol-13-Acetate)  inhibits mammary cancer stem cell proliferation via down regulation of Wnt receptor FZD7.  This study may suggest that TPA, by down regulating its target gene, it may inhibit the Wnt pathway. Together, this study suggests that pharmacological formulations encompassing “TPA or its analogues can be used to inhibit tumor initiating mammary cancer cells.

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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To citeBoominathan, Anti-cancer Stem cell  therapeutics: TPA inhibits mammary cancer stem cell proliferation via down regulation of Wnt receptor FZD7, 04/October/2014, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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