Interleukin-based Differentiation therapy for Human Leukaemia: Interleukin-1β (IL-1β) functions as an anti-cancer barrier by promoting differentiation of leukaemic cells via up regulation of Histone methyl-transferase MLL4, 6/October/2014, 4.50 am

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A recent study from the Laboratory of Genome Integrity, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA shows that “DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier.” This study was published in the 27 July  2014 issue of Nature  by Prof André NussenzweigMargarida A. Santos, and others.

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMDreports that:  Interleukin-based Differentiation therapy for Human Leukaemia: Interleukin-1β (IL-1β) functions as an anti-cancer barrier by promoting differentiation of leukaemic cells via up regulation of Histone methyl-transferase MLL4. By increasing the expression of IL-1β in myeloid leukaemic cells, one may promote differentiation of leukaemic cells. Together, this study suggests that pharmacological formulations encompassinIL-1β or its activators” may be used to treat human leukaemia.

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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To citeBoominathan,  Interleukin-based Differentiation therapy for Human Leukaemia: Interleukin-1β (IL-1β) functions as an anti-cancer barrier by promoting differentiation of leukaemic cells via up regulation of Histone methyl-transferase MLL4, 6/October/2014,  4.50 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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