Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Citation: Boominathan, Molecular therapy for cancer: Endothelin-1 suppresses the expression of Notch1 and Notch2 via up regulation of its target gene, 18/October/2014, 7.43 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Significance: This study suggests that Endothelin-1, by increasing the expression of its target gene, it may suppress the expression of Notch1 and Notch2. Thus, pharmacological formulations encompassing “Endothelin-1 activators“ may be used to inhibit tumorigenesis and metastasis.